Interactions between vagal afferent nerve subtypes mediating cough

Research output: Contribution to journalArticlepeer-review

Abstract

The cough reflex is initiated through activation of vagal afferent nerves. Rapidly adapting receptors fulfill all criteria for the afferents subserving the cough reflex. Bronchopulmonary C-fibres may also initiate cough when activated. C-fibre-mediated cough may depend upon ongoing or initiated activity in rapidly adapting receptors. The interaction between airways C-fibres and rapidly adapting receptors may occur at sites in the periphery or in the brainstem. C-fibre mediated cough must also overcome a coincident inhibitory effect of C-fibre activation on cough, an inhibitory effect that becomes prominent under general anesthaesia.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalPulmonary Pharmacology and Therapeutics
Volume15
Issue number3
DOIs
StatePublished - 2002

Keywords

  • Axon Reflex
  • Bronchospasm
  • Central Sensitization
  • Neurokinins

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Biochemistry, medical
  • Pharmacology (medical)

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