Abstract
The cough reflex is initiated through activation of vagal afferent nerves. Rapidly adapting receptors fulfill all criteria for the afferents subserving the cough reflex. Bronchopulmonary C-fibres may also initiate cough when activated. C-fibre-mediated cough may depend upon ongoing or initiated activity in rapidly adapting receptors. The interaction between airways C-fibres and rapidly adapting receptors may occur at sites in the periphery or in the brainstem. C-fibre mediated cough must also overcome a coincident inhibitory effect of C-fibre activation on cough, an inhibitory effect that becomes prominent under general anesthaesia.
Original language | English (US) |
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Pages (from-to) | 187-192 |
Number of pages | 6 |
Journal | Pulmonary Pharmacology and Therapeutics |
Volume | 15 |
Issue number | 3 |
DOIs | |
State | Published - 2002 |
Keywords
- Axon Reflex
- Bronchospasm
- Central Sensitization
- Neurokinins
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Biochemistry, medical
- Pharmacology (medical)