Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease

Irina Costea, David R. MacK, Rozenn N. Lemaitre, David Israel, Valerie Marcil, Ali Ahmad, Devendra K. Amre

Research output: Contribution to journalArticle

Abstract

Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.

Original languageEnglish (US)
JournalGastroenterology
Volume146
Issue number4
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Unsaturated Fatty Acids
Crohn Disease
Genes
Pediatric Crohn's disease
Diet

Keywords

  • DNA
  • Fat Content
  • Food
  • Inflammatory Bowel Disease

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease. / Costea, Irina; MacK, David R.; Lemaitre, Rozenn N.; Israel, David; Marcil, Valerie; Ahmad, Ali; Amre, Devendra K.

In: Gastroenterology, Vol. 146, No. 4, 2014.

Research output: Contribution to journalArticle

Costea, Irina ; MacK, David R. ; Lemaitre, Rozenn N. ; Israel, David ; Marcil, Valerie ; Ahmad, Ali ; Amre, Devendra K. / Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease. In: Gastroenterology. 2014 ; Vol. 146, No. 4.
@article{532f4286fd0b40b7b523463a4b4d40dd,
title = "Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease",
abstract = "Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.",
keywords = "DNA, Fat Content, Food, Inflammatory Bowel Disease",
author = "Irina Costea and MacK, {David R.} and Lemaitre, {Rozenn N.} and David Israel and Valerie Marcil and Ali Ahmad and Amre, {Devendra K.}",
year = "2014",
doi = "10.1053/j.gastro.2013.12.034",
language = "English (US)",
volume = "146",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease

AU - Costea, Irina

AU - MacK, David R.

AU - Lemaitre, Rozenn N.

AU - Israel, David

AU - Marcil, Valerie

AU - Ahmad, Ali

AU - Amre, Devendra K.

PY - 2014

Y1 - 2014

N2 - Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.

AB - Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.

KW - DNA

KW - Fat Content

KW - Food

KW - Inflammatory Bowel Disease

UR - http://www.scopus.com/inward/record.url?scp=84896461847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896461847&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2013.12.034

DO - 10.1053/j.gastro.2013.12.034

M3 - Article

C2 - 24406470

AN - SCOPUS:84896461847

VL - 146

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 4

ER -