Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease

Irina Costea; David R. MacK; Rozenn N. Lemaitre; David Israel; Valerie Marcil; Ali Ahmad; Devendra K. Amre

doi:10.1053/j.gastro.2013.12.034

Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease

Irina Costea, David R. MacK, Rozenn N. Lemaitre, David Israel, Valerie Marcil, Ali Ahmad, Devendra K. Amre

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.

Original language	English (US)
Pages (from-to)	929-931.e3
Journal	Gastroenterology
Volume	146
Issue number	4
DOIs	https://doi.org/10.1053/j.gastro.2013.12.034
State	Published - Apr 2014
Externally published	Yes

Keywords

DNA
Fat Content
Food
Inflammatory Bowel Disease

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1053/j.gastro.2013.12.034

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title = "Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease",

abstract = "Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.",

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AU - Costea, Irina

AU - MacK, David R.

AU - Lemaitre, Rozenn N.

AU - Israel, David

AU - Marcil, Valerie

AU - Ahmad, Ali

AU - Amre, Devendra K.

PY - 2014/4

Y1 - 2014/4

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AB - Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.

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KW - Food

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Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease

Abstract

Keywords

ASJC Scopus subject areas

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