Abstract
A series of linear tetrapeptides containing two histidyl residues in positions 2 and 4 with different chirality: DHGH, DHG(d-His), KHGH, KHG(d-His), Ac-DHGH-NH2, Ac-DHG(d-His)-NH2, Ac-KHGH-NH2, and Ac-KHG(d-His)-NH2 were synthesized, characterized and their binding properties towards Ni2+ were investigated. To establish the stoichiometry and the stability of the resulting Ni2+ complexes, potentiometric titrations were carried out. The coordination mode of the complexes formed was investigated by performing extensive spectroscopic analyses (UV-Vis, CD) in strict correlation with the potentiometric results. The effects of the nature of the first amino acid (Lys versus Asp) and of the N-terminal amino group acetylation were determined. A careful comparison of the Ni 2+ coordination abilities of the linear peptides provides a specific insight into the impact of the chirality of the C-terminal histidine residue (His4) on the metal binding properties.
Original language | English (US) |
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Pages (from-to) | 3052-3058 |
Number of pages | 7 |
Journal | Polyhedron |
Volume | 29 |
Issue number | 16 |
DOIs | |
State | Published - Oct 29 2010 |
Externally published | Yes |
Keywords
- Bioinorganic chemistry
- Chirality
- Histidyl residue
- Nickel ions
- Peptides
ASJC Scopus subject areas
- Inorganic Chemistry
- Materials Chemistry
- Physical and Theoretical Chemistry