Interactions between highly active antiretroviral therapy and over-the-counter agents: A cautionary note

Jerome Federspiel, Melanie J. Bukhari, Matthew M. Hamill

Research output: Contribution to journalArticlepeer-review

Abstract

Highly active antiretroviral therapy (HAART) has dramatically lowered rates of mother-to-child HIV transmission among patients with access to treatment. Barriers to complete viral suppression increase rates of transmission, even with only low levels of viral replication. Here, we present the case of a pregnant patient who developed a detectable viral load in pregnancy, thought to be related to calcium supplement consumption or emesis while using a dolutegravir-based HAART regimen. Ultimately, with adjustments, the patient again reached an undetectable viral load and had an uncomplicated perinatal and neonatal outcome. We discuss new data on the use of dolutegravir in pregnancy and precautions for maintaining viral suppression while on antiretroviral therapy in pregnancy.

Original languageEnglish (US)
Article numbere236655
JournalBMJ case reports
Volume14
Issue number1
DOIs
StatePublished - Jan 6 2021

Keywords

  • HIV / AIDS
  • pregnancy

ASJC Scopus subject areas

  • Medicine(all)

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