Interactions between calcium and reactive oxygen species in pulmonary arterial smooth muscle responses to hypoxia

Larissa A. Shimoda, Clark Undem

Research output: Contribution to journalReview article


In contrast to the systemic vasculature, where hypoxia causes vasodilation, pulmonary arteries constrict in response to hypoxia. The mechanisms underlying this unique response have been the subject of investigation for over 50 years, and still remain a topic of great debate. Over the last 20 years, there has emerged a general consensus that both increases in intracellular calcium concentration and changes in reactive oxygen species (ROS) generation play key roles in the pulmonary vascular response to hypoxia. Controversy exists, however, regarding whether ROS increase or decrease during hypoxia, the source of ROS, and the mechanisms by which changes in ROS might impact intracellular calcium, and vice versa. This review will discuss the mechanisms regulating [Ca2+]i and ROS in PASMCs, and the interaction between ROS and Ca2+ signaling during exposure to acute hypoxia.

Original languageEnglish (US)
Pages (from-to)221-229
Number of pages9
JournalRespiratory Physiology and Neurobiology
Issue number3
StatePublished - Dec 31 2010



  • Mitochondria
  • PASMCs
  • Ventilation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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