TY - JOUR
T1 - Interactions between calcium and reactive oxygen species in pulmonary arterial smooth muscle responses to hypoxia
AU - Shimoda, Larissa A.
AU - Undem, Clark
N1 - Funding Information:
Due to space restrictions, it was not possible to quote all of the excellent studies that have been published with respect to the research described in this review; our apologies to those whose studies were not cited. This work was supported by the National Institutes of Health ( HL 67191 ).
PY - 2010/12/31
Y1 - 2010/12/31
N2 - In contrast to the systemic vasculature, where hypoxia causes vasodilation, pulmonary arteries constrict in response to hypoxia. The mechanisms underlying this unique response have been the subject of investigation for over 50 years, and still remain a topic of great debate. Over the last 20 years, there has emerged a general consensus that both increases in intracellular calcium concentration and changes in reactive oxygen species (ROS) generation play key roles in the pulmonary vascular response to hypoxia. Controversy exists, however, regarding whether ROS increase or decrease during hypoxia, the source of ROS, and the mechanisms by which changes in ROS might impact intracellular calcium, and vice versa. This review will discuss the mechanisms regulating [Ca2+]i and ROS in PASMCs, and the interaction between ROS and Ca2+ signaling during exposure to acute hypoxia.
AB - In contrast to the systemic vasculature, where hypoxia causes vasodilation, pulmonary arteries constrict in response to hypoxia. The mechanisms underlying this unique response have been the subject of investigation for over 50 years, and still remain a topic of great debate. Over the last 20 years, there has emerged a general consensus that both increases in intracellular calcium concentration and changes in reactive oxygen species (ROS) generation play key roles in the pulmonary vascular response to hypoxia. Controversy exists, however, regarding whether ROS increase or decrease during hypoxia, the source of ROS, and the mechanisms by which changes in ROS might impact intracellular calcium, and vice versa. This review will discuss the mechanisms regulating [Ca2+]i and ROS in PASMCs, and the interaction between ROS and Ca2+ signaling during exposure to acute hypoxia.
KW - Mitochondria
KW - PASMCs
KW - Ventilation
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U2 - 10.1016/j.resp.2010.08.014
DO - 10.1016/j.resp.2010.08.014
M3 - Review article
C2 - 20801238
AN - SCOPUS:78449268302
SN - 1569-9048
VL - 174
SP - 221
EP - 229
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 3
ER -