TY - JOUR
T1 - Interactions between airway nerves and inflammation
AU - Undem, B. J.
PY - 2000
Y1 - 2000
N2 - The airways are richly innervated by sensory, parasympathetic, and to a lesser extent, sympathetic nerves. The nerves in the airways assist in maintaining homeostasis in the airways, as well as serving vital defense functions. With respect to defending the airways, the nervous system can lead through coughing, sneezing, and regulation of the inflammatory response. The inflammatory response in the airway leads to the production of various chemical mediators that can excite and modulate airway neurons. Conversely, stimulation of airway neurons can enhance or inhibit various aspects of the inflammatory response. This bidirectional interaction between the nervous system and immune-inflammatory system ideally serves to protect the host, but malfunction in this interactive process may lead to airway inflammatory disease.
AB - The airways are richly innervated by sensory, parasympathetic, and to a lesser extent, sympathetic nerves. The nerves in the airways assist in maintaining homeostasis in the airways, as well as serving vital defense functions. With respect to defending the airways, the nervous system can lead through coughing, sneezing, and regulation of the inflammatory response. The inflammatory response in the airway leads to the production of various chemical mediators that can excite and modulate airway neurons. Conversely, stimulation of airway neurons can enhance or inhibit various aspects of the inflammatory response. This bidirectional interaction between the nervous system and immune-inflammatory system ideally serves to protect the host, but malfunction in this interactive process may lead to airway inflammatory disease.
UR - http://www.scopus.com/inward/record.url?scp=0034030873&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034030873&partnerID=8YFLogxK
U2 - 10.1027/0838-1925.12.2.60
DO - 10.1027/0838-1925.12.2.60
M3 - Short survey
AN - SCOPUS:0034030873
SN - 0838-1925
VL - 12
SP - 60
EP - 62
JO - Allergy and Clinical Immunology International
JF - Allergy and Clinical Immunology International
IS - 2
ER -