Interaction of the glutathione S-transferase genes and cigarette smoking on risk of lower extremity arterial disease: The Atherosclerosis Risk in Communities (ARIC) study

Rongling Li, Aaron R. Folsom, A. Richey Sharrett, David Couper, Molly Bray, Herman A. Tyroler

Research output: Contribution to journalArticle

Abstract

Glutathione S-transferases M1 or T1 (GSTM1/GSTT1) affect the body's ability either to detoxify or to activate chemicals in cigarette smoke. Cigarette smoking increases the risk of lower extremity arterial disease (LEAD). We conducted a cross-sectional study to evaluate a hypothesized interaction of the genetic polymorphisms of GSTM1 and T1 with cigarette smoking in the risk of LEAD in the ARIC study. A stratified-random sample, including 212 LEAD cases (ankle-brachial index

Original languageEnglish (US)
Pages (from-to)729-738
Number of pages10
JournalAtherosclerosis
Volume154
Issue number3
DOIs
StatePublished - Feb 15 2001
Externally publishedYes

Fingerprint

Glutathione Transferase
Lower Extremity
Atherosclerosis
Smoking
Genes
Ankle Brachial Index
Aptitude
Genetic Polymorphisms
Smoke
Tobacco Products
Cross-Sectional Studies

Keywords

  • Gene-smoking interaction
  • GSTM1
  • GSTT1
  • Lower extremity arterial disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Interaction of the glutathione S-transferase genes and cigarette smoking on risk of lower extremity arterial disease : The Atherosclerosis Risk in Communities (ARIC) study. / Li, Rongling; Folsom, Aaron R.; Sharrett, A. Richey; Couper, David; Bray, Molly; Tyroler, Herman A.

In: Atherosclerosis, Vol. 154, No. 3, 15.02.2001, p. 729-738.

Research output: Contribution to journalArticle

Li, Rongling ; Folsom, Aaron R. ; Sharrett, A. Richey ; Couper, David ; Bray, Molly ; Tyroler, Herman A. / Interaction of the glutathione S-transferase genes and cigarette smoking on risk of lower extremity arterial disease : The Atherosclerosis Risk in Communities (ARIC) study. In: Atherosclerosis. 2001 ; Vol. 154, No. 3. pp. 729-738.
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