Interaction of sex steroid hormones and obesity on insulin resistance and type 2 diabetes in men: The Third National Health and Nutrition Examination Survey

Ji Li, Hong Chen Lai, Shaoguang Chen, Hong Zhu, Shenghan Lai

Research output: Contribution to journalArticle

Abstract

Aims: We examined interaction of sex steroid hormones and obesity with regard to insulin resistance (IR) and type 2 diabetes (T2D) by using nationally representative data from the US. Methods: Data of 1461 men aged ≥. 20. years who participated in the Third National Health and Nutrition Examination Survey were analyzed. Multiplicative interaction was calculated by cross-product interaction terms in multivariable logistic regression models. Additive interaction was assessed by the relative excess risk due to interaction (RERI). Results: After adjusting for demographic and lifestyle covariates, the odds of IR were greatest among obese men with low free testosterone and high androstanediol glucuronide. Multiplicative interactions for total testosterone, free testosterone, and free estradiol index (FEI) were statistically significant with central obesity but not with overweight and obesity regarding to T2D (P < 0.05). Significant additive interactions with obesity or central obesity were detected for total testosterone (RERI = 2.75, 95% CI = 0.92,4.59), SHBG (RERI = 5.71, 95% CI = 0.77,10.64), and FEI (RERI = -9.96, 95% CI = -19.18,-0.74) with regard to IR, beta-cell dysfunction, and T2D. Conclusions: Our findings add to the evidence suggesting that low testosterone and high estradiol may be associated greater risks of IR and T2D by interacting with overall and central obesity in adult men.

Original languageEnglish (US)
JournalJournal of Diabetes and its Complications
DOIs
StateAccepted/In press - Mar 22 2016

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Nutrition Surveys
Gonadal Steroid Hormones
Type 2 Diabetes Mellitus
Insulin Resistance
Testosterone
Obesity
Abdominal Obesity
Estradiol
Logistic Models
Glucuronides
Life Style
Demography

Keywords

  • Insulin resistance
  • Men
  • NHANES
  • Obesity
  • Sex steroid hormones
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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title = "Interaction of sex steroid hormones and obesity on insulin resistance and type 2 diabetes in men: The Third National Health and Nutrition Examination Survey",
abstract = "Aims: We examined interaction of sex steroid hormones and obesity with regard to insulin resistance (IR) and type 2 diabetes (T2D) by using nationally representative data from the US. Methods: Data of 1461 men aged ≥. 20. years who participated in the Third National Health and Nutrition Examination Survey were analyzed. Multiplicative interaction was calculated by cross-product interaction terms in multivariable logistic regression models. Additive interaction was assessed by the relative excess risk due to interaction (RERI). Results: After adjusting for demographic and lifestyle covariates, the odds of IR were greatest among obese men with low free testosterone and high androstanediol glucuronide. Multiplicative interactions for total testosterone, free testosterone, and free estradiol index (FEI) were statistically significant with central obesity but not with overweight and obesity regarding to T2D (P < 0.05). Significant additive interactions with obesity or central obesity were detected for total testosterone (RERI = 2.75, 95{\%} CI = 0.92,4.59), SHBG (RERI = 5.71, 95{\%} CI = 0.77,10.64), and FEI (RERI = -9.96, 95{\%} CI = -19.18,-0.74) with regard to IR, beta-cell dysfunction, and T2D. Conclusions: Our findings add to the evidence suggesting that low testosterone and high estradiol may be associated greater risks of IR and T2D by interacting with overall and central obesity in adult men.",
keywords = "Insulin resistance, Men, NHANES, Obesity, Sex steroid hormones, Type 2 diabetes",
author = "Ji Li and Lai, {Hong Chen} and Shaoguang Chen and Hong Zhu and Shenghan Lai",
year = "2016",
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language = "English (US)",
journal = "Journal of Diabetes and its Complications",
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TY - JOUR

T1 - Interaction of sex steroid hormones and obesity on insulin resistance and type 2 diabetes in men

T2 - The Third National Health and Nutrition Examination Survey

AU - Li, Ji

AU - Lai, Hong Chen

AU - Chen, Shaoguang

AU - Zhu, Hong

AU - Lai, Shenghan

PY - 2016/3/22

Y1 - 2016/3/22

N2 - Aims: We examined interaction of sex steroid hormones and obesity with regard to insulin resistance (IR) and type 2 diabetes (T2D) by using nationally representative data from the US. Methods: Data of 1461 men aged ≥. 20. years who participated in the Third National Health and Nutrition Examination Survey were analyzed. Multiplicative interaction was calculated by cross-product interaction terms in multivariable logistic regression models. Additive interaction was assessed by the relative excess risk due to interaction (RERI). Results: After adjusting for demographic and lifestyle covariates, the odds of IR were greatest among obese men with low free testosterone and high androstanediol glucuronide. Multiplicative interactions for total testosterone, free testosterone, and free estradiol index (FEI) were statistically significant with central obesity but not with overweight and obesity regarding to T2D (P < 0.05). Significant additive interactions with obesity or central obesity were detected for total testosterone (RERI = 2.75, 95% CI = 0.92,4.59), SHBG (RERI = 5.71, 95% CI = 0.77,10.64), and FEI (RERI = -9.96, 95% CI = -19.18,-0.74) with regard to IR, beta-cell dysfunction, and T2D. Conclusions: Our findings add to the evidence suggesting that low testosterone and high estradiol may be associated greater risks of IR and T2D by interacting with overall and central obesity in adult men.

AB - Aims: We examined interaction of sex steroid hormones and obesity with regard to insulin resistance (IR) and type 2 diabetes (T2D) by using nationally representative data from the US. Methods: Data of 1461 men aged ≥. 20. years who participated in the Third National Health and Nutrition Examination Survey were analyzed. Multiplicative interaction was calculated by cross-product interaction terms in multivariable logistic regression models. Additive interaction was assessed by the relative excess risk due to interaction (RERI). Results: After adjusting for demographic and lifestyle covariates, the odds of IR were greatest among obese men with low free testosterone and high androstanediol glucuronide. Multiplicative interactions for total testosterone, free testosterone, and free estradiol index (FEI) were statistically significant with central obesity but not with overweight and obesity regarding to T2D (P < 0.05). Significant additive interactions with obesity or central obesity were detected for total testosterone (RERI = 2.75, 95% CI = 0.92,4.59), SHBG (RERI = 5.71, 95% CI = 0.77,10.64), and FEI (RERI = -9.96, 95% CI = -19.18,-0.74) with regard to IR, beta-cell dysfunction, and T2D. Conclusions: Our findings add to the evidence suggesting that low testosterone and high estradiol may be associated greater risks of IR and T2D by interacting with overall and central obesity in adult men.

KW - Insulin resistance

KW - Men

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