TY - JOUR
T1 - Interaction of propoxyphene with diazepam, alprazolam and lorazepam.
AU - Abernethy, DR
AU - Greenblatt, DJ
AU - Morse, DS
AU - Shader, RI
PY - 1985/1
Y1 - 1985/1
N2 - Healthy volunteers received single doses of three benzodiazepines (diazepam, 10 mg i.v.; alprazolam, 1.0 mg orally; lorazepam, 2 mg i.v.) on two occasions in random sequence. One trial was a control; for the other, subjects ingested propoxyphene, 65 mg every 6 h, for the duration of the benzodiazepine study. The kinetics of each benzodiazepine were determined from multiple plasma concentrations measured following each dose. For diazepam, propoxyphene produced a small and statistically insignificant prolongation of elimination half‐ life (43 vs 38 h) and reduction of total clearance (0.41 vs 0.47 ml min‐ 1 kg‐1). Propoxyphene significantly prolonged alprazolam half‐life (18 vs 12 h, P less than 0.005) and reduced total clearance (0.8 vs 1.3 ml min‐1 kg‐1, P less than 0.005). Propoxyphene had no apparent influence on lorazepam half‐life (13.4 vs 13.5 h) or clearance (1.5 vs 1.4 ml min‐ 1 kg‐1). Thus propoxyphene significantly impairs the clearance of alprazolam, biotransformed mainly by the oxidative reaction of aliphatic hydroxylation. Propoxyphene has far less effect on the oxidation of diazepam by N‐demethylation, and has no apparent influence on lorazepam conjugation. 1985 The British Pharmacological Society
AB - Healthy volunteers received single doses of three benzodiazepines (diazepam, 10 mg i.v.; alprazolam, 1.0 mg orally; lorazepam, 2 mg i.v.) on two occasions in random sequence. One trial was a control; for the other, subjects ingested propoxyphene, 65 mg every 6 h, for the duration of the benzodiazepine study. The kinetics of each benzodiazepine were determined from multiple plasma concentrations measured following each dose. For diazepam, propoxyphene produced a small and statistically insignificant prolongation of elimination half‐ life (43 vs 38 h) and reduction of total clearance (0.41 vs 0.47 ml min‐ 1 kg‐1). Propoxyphene significantly prolonged alprazolam half‐life (18 vs 12 h, P less than 0.005) and reduced total clearance (0.8 vs 1.3 ml min‐1 kg‐1, P less than 0.005). Propoxyphene had no apparent influence on lorazepam half‐life (13.4 vs 13.5 h) or clearance (1.5 vs 1.4 ml min‐ 1 kg‐1). Thus propoxyphene significantly impairs the clearance of alprazolam, biotransformed mainly by the oxidative reaction of aliphatic hydroxylation. Propoxyphene has far less effect on the oxidation of diazepam by N‐demethylation, and has no apparent influence on lorazepam conjugation. 1985 The British Pharmacological Society
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U2 - 10.1111/j.1365-2125.1985.tb02612.x
DO - 10.1111/j.1365-2125.1985.tb02612.x
M3 - Article
C2 - 2858217
AN - SCOPUS:0021933741
SN - 0306-5251
VL - 19
SP - 51
EP - 57
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
IS - 1
ER -