Interaction of Listeria monocytogenes with human brain microvascular endothelial cells: An electron microscopic study

Lars Greiffenberg, Werner Goebel, Kwang Sik Kim, Justin Daniels, Michael Kuhn

Research output: Contribution to journalArticlepeer-review

Abstract

Internalization of Listeria monocytogenes into human brain microvascular endothelial cells (HBMEC) has recently been demonstrated to be dependent upon the inlB gene. In the present scanning electron microscopic study we show that L. monocytogenes efficiently interacts with the surface of HBMEC in an inlB-independent manner which is also different from invasion. The inlB- dependent invasion of HBMEC by L. monocytogenes is accompanied by intracellular multiplication, movement, and production of bacterium- containing protrusions. These protrusions extend from the cell surface without perturbation of any adjacent cellular membrane.

Original languageEnglish (US)
Pages (from-to)3275-3279
Number of pages5
JournalInfection and immunity
Volume68
Issue number6
DOIs
StatePublished - Jun 2000

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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