Interaction of levodopa and cues on voluntary reaching in Parkinson's disease

Valerie E. Kelly, Allie S. Hyngstrom, Melissa M. Rundle, Amy J Bastian

Research output: Contribution to journalArticle

Abstract

The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined the combined effect of levodopa and external cueing on the voluntary reaching movements of individuals with PD. Nine subjects with PD and nine matched controls were studied reaching to a ball target. Subjects with PD were studied after being off levodopa overnight and again on their morning dose. Kinematic data were collected as all subjects made both accurate and fast reaches under two different cue conditions: noncued (self-initiated) and cued (triggered by a light). Subjects with PD reached more slowly than controls under all conditions. PD subjects increased their reach velocity and decreased movement time after taking levodopa and also when moving to a cue. However, the effects of levodopa and cueing were not additive. Instead, levodopa improved reach velocity to a greater extent in the noncued vs. cued condition. We also found that levodopa improved accurate (self-paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated.

Original languageEnglish (US)
Pages (from-to)38-44
Number of pages7
JournalMovement disorders : official journal of the Movement Disorder Society
Volume17
Issue number1
DOIs
StatePublished - Jan 2002
Externally publishedYes

Fingerprint

Levodopa
Cues
Parkinson Disease
Hypokinesia
Biomechanical Phenomena
Light

Keywords

  • Bradykinesia
  • External cues
  • Levodopa
  • Movement
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Interaction of levodopa and cues on voluntary reaching in Parkinson's disease. / Kelly, Valerie E.; Hyngstrom, Allie S.; Rundle, Melissa M.; Bastian, Amy J.

In: Movement disorders : official journal of the Movement Disorder Society, Vol. 17, No. 1, 01.2002, p. 38-44.

Research output: Contribution to journalArticle

@article{439b14f1ec5348309bd0e9ad6d4543e4,
title = "Interaction of levodopa and cues on voluntary reaching in Parkinson's disease",
abstract = "The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined the combined effect of levodopa and external cueing on the voluntary reaching movements of individuals with PD. Nine subjects with PD and nine matched controls were studied reaching to a ball target. Subjects with PD were studied after being off levodopa overnight and again on their morning dose. Kinematic data were collected as all subjects made both accurate and fast reaches under two different cue conditions: noncued (self-initiated) and cued (triggered by a light). Subjects with PD reached more slowly than controls under all conditions. PD subjects increased their reach velocity and decreased movement time after taking levodopa and also when moving to a cue. However, the effects of levodopa and cueing were not additive. Instead, levodopa improved reach velocity to a greater extent in the noncued vs. cued condition. We also found that levodopa improved accurate (self-paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated.",
keywords = "Bradykinesia, External cues, Levodopa, Movement, Parkinson's disease",
author = "Kelly, {Valerie E.} and Hyngstrom, {Allie S.} and Rundle, {Melissa M.} and Bastian, {Amy J}",
year = "2002",
month = "1",
doi = "10.1002/mds.10000",
language = "English (US)",
volume = "17",
pages = "38--44",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Interaction of levodopa and cues on voluntary reaching in Parkinson's disease

AU - Kelly, Valerie E.

AU - Hyngstrom, Allie S.

AU - Rundle, Melissa M.

AU - Bastian, Amy J

PY - 2002/1

Y1 - 2002/1

N2 - The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined the combined effect of levodopa and external cueing on the voluntary reaching movements of individuals with PD. Nine subjects with PD and nine matched controls were studied reaching to a ball target. Subjects with PD were studied after being off levodopa overnight and again on their morning dose. Kinematic data were collected as all subjects made both accurate and fast reaches under two different cue conditions: noncued (self-initiated) and cued (triggered by a light). Subjects with PD reached more slowly than controls under all conditions. PD subjects increased their reach velocity and decreased movement time after taking levodopa and also when moving to a cue. However, the effects of levodopa and cueing were not additive. Instead, levodopa improved reach velocity to a greater extent in the noncued vs. cued condition. We also found that levodopa improved accurate (self-paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated.

AB - The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined the combined effect of levodopa and external cueing on the voluntary reaching movements of individuals with PD. Nine subjects with PD and nine matched controls were studied reaching to a ball target. Subjects with PD were studied after being off levodopa overnight and again on their morning dose. Kinematic data were collected as all subjects made both accurate and fast reaches under two different cue conditions: noncued (self-initiated) and cued (triggered by a light). Subjects with PD reached more slowly than controls under all conditions. PD subjects increased their reach velocity and decreased movement time after taking levodopa and also when moving to a cue. However, the effects of levodopa and cueing were not additive. Instead, levodopa improved reach velocity to a greater extent in the noncued vs. cued condition. We also found that levodopa improved accurate (self-paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated.

KW - Bradykinesia

KW - External cues

KW - Levodopa

KW - Movement

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=0036460910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036460910&partnerID=8YFLogxK

U2 - 10.1002/mds.10000

DO - 10.1002/mds.10000

M3 - Article

C2 - 11835437

AN - SCOPUS:0036460910

VL - 17

SP - 38

EP - 44

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 1

ER -