Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam

Darrell R. Abernethy, David J. Greenblatt, Divoll Divoll, Lawrence J. Moschitto, Jerold S. Harmatz, Richard I. Shader

Research output: Contribution to journalArticle

Abstract

The influence of cimetidine on the pharmacokinetics of alprazolam and triazolam, two triazolobenzodiazepines metabolized by hepatic microsomal oxidation, was evaluated in a series of healthy volunteers. Subjects ingested single 1.0 mg dose of alprazolam or 0.5 mg doses of triazolam on two occasions, with and without concurrent administration of cimetidine (300 mg) every 6h. For alprazolam, which has a low hepatic clearance and low extraction ratio, cimetidine significantly impaired total metabolic clearance (1.05 versus 1.66 ml/min/kg, P

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalPsychopharmacology
Volume80
Issue number3
DOIs
StatePublished - Jun 1983
Externally publishedYes

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Triazolam
Alprazolam
Cimetidine
Liver
Healthy Volunteers
Pharmacokinetics

Keywords

  • Alprazolam
  • Cimetidine
  • Triazolam
  • Triazolobenzodiazepine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Abernethy, D. R., Greenblatt, D. J., Divoll, D., Moschitto, L. J., Harmatz, J. S., & Shader, R. I. (1983). Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam. Psychopharmacology, 80(3), 275-278. https://doi.org/10.1007/BF00436169

Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam. / Abernethy, Darrell R.; Greenblatt, David J.; Divoll, Divoll; Moschitto, Lawrence J.; Harmatz, Jerold S.; Shader, Richard I.

In: Psychopharmacology, Vol. 80, No. 3, 06.1983, p. 275-278.

Research output: Contribution to journalArticle

Abernethy, DR, Greenblatt, DJ, Divoll, D, Moschitto, LJ, Harmatz, JS & Shader, RI 1983, 'Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam', Psychopharmacology, vol. 80, no. 3, pp. 275-278. https://doi.org/10.1007/BF00436169
Abernethy DR, Greenblatt DJ, Divoll D, Moschitto LJ, Harmatz JS, Shader RI. Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam. Psychopharmacology. 1983 Jun;80(3):275-278. https://doi.org/10.1007/BF00436169
Abernethy, Darrell R. ; Greenblatt, David J. ; Divoll, Divoll ; Moschitto, Lawrence J. ; Harmatz, Jerold S. ; Shader, Richard I. / Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam. In: Psychopharmacology. 1983 ; Vol. 80, No. 3. pp. 275-278.
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