Interaction of amyloid precursor proteins and heme oxygenase

Masaaki Takahashi, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Amyloid precursor protein generates the β-amyloid peptide and is a member of a multigene family that contains at least two other gene products, known as amyloid precursor-like proteins. Heme oxygenase is an enzyme whose products are antioxidant and neuroprotective. The authors report that amyloid precursor protein and amyloid precursor-like protein bind to heme oxygenase to inhibit its enzymatic activity. Our findings suggest that decreased neuroprotection caused by amyloid precursor protein-heme oxygenase interactions influences neurotoxicity in Alzheimer disease.

Original languageEnglish (US)
JournalAlzheimer Disease and Associated Disorders
Volume14
Issue numberSUPPL. 1
DOIs
StatePublished - 2000

Fingerprint

Heme Oxygenase (Decyclizing)
Amyloid beta-Protein Precursor
Multigene Family
Amyloid
Alzheimer Disease
Antioxidants
Peptides
Enzymes
Genes
Proteins

Keywords

  • Amyloid precursor protein
  • Heme oxygenase
  • Oxidative stress

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Interaction of amyloid precursor proteins and heme oxygenase. / Takahashi, Masaaki; Snyder, Solomon H.

In: Alzheimer Disease and Associated Disorders, Vol. 14, No. SUPPL. 1, 2000.

Research output: Contribution to journalArticle

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