Interaction of amyloid precursor proteins and heme oxygenase

Masaaki Takahashi, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Amyloid precursor protein generates the β-amyloid peptide and is a member of a multigene family that contains at least two other gene products, known as amyloid precursor-like proteins. Heme oxygenase is an enzyme whose products are antioxidant and neuroprotective. The authors report that amyloid precursor protein and amyloid precursor-like protein bind to heme oxygenase to inhibit its enzymatic activity. Our findings suggest that decreased neuroprotection caused by amyloid precursor protein-heme oxygenase interactions influences neurotoxicity in Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)S67-S71
JournalAlzheimer disease and associated disorders
Volume14
Issue numberSUPPL. 1
DOIs
StatePublished - Jul 6 2000

Keywords

  • Amyloid precursor protein
  • Heme oxygenase
  • Oxidative stress

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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