Interaction of Age and Thyroid Hormone Status on Na+-K+ ATPase in Rat Renal Cortex and Liver

S. R. Gambert; S. H. Ingbar; T. C. Hagen

doi:10.1210/endo-108-1-27

Interaction of Age and Thyroid Hormone Status on Na⁺-K⁺ ATPase in Rat Renal Cortex and Liver

S. R. Gambert, S. H. Ingbar, T. C. Hagen

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Na^ʻ-K^ʻ ATPase was measured in euthyroid, hypothyroid, and hyperthyroid rats aged 6 weeks, 6 months, and 20-24 months. There was a small but significant decline in basal enzyme activity with increasing age in renal cortical tissue. Enzyme activity decreased with hypothyroidism and increased with hyperthyroidism. With increasing age, both the magnitude of the increase resulting from thyrotoxicosis and the absolute enzyme level were significantly less with each increase in the age of the experimental animals. Hypothyroid animals displayed no age-related decline in renal cortical Na^ʻ-K^ʻ ATPase. The decline in Na^ʻ-K^ʻ ATPase in renal cortical tissue is thyroid hormone dependent. In addition, age modifies the response of Na^ʻʻ ATPase to thyroid hormone.

Original language	English (US)
Pages (from-to)	27-30
Number of pages	4
Journal	Endocrinology
Volume	108
Issue number	1
DOIs	https://doi.org/10.1210/endo-108-1-27
State	Published - Jan 1981
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

Access to Document

10.1210/endo-108-1-27

Cite this

@article{a817add1468444919f08342317cbe519,

title = "Interaction of Age and Thyroid Hormone Status on Na+-K+ ATPase in Rat Renal Cortex and Liver",

abstract = "Naʻ-Kʻ ATPase was measured in euthyroid, hypothyroid, and hyperthyroid rats aged 6 weeks, 6 months, and 20-24 months. There was a small but significant decline in basal enzyme activity with increasing age in renal cortical tissue. Enzyme activity decreased with hypothyroidism and increased with hyperthyroidism. With increasing age, both the magnitude of the increase resulting from thyrotoxicosis and the absolute enzyme level were significantly less with each increase in the age of the experimental animals. Hypothyroid animals displayed no age-related decline in renal cortical Naʻ-Kʻ ATPase. The decline in Naʻ-Kʻ ATPase in renal cortical tissue is thyroid hormone dependent. In addition, age modifies the response of Naʻʻ ATPase to thyroid hormone.",

author = "Gambert, {S. R.} and Ingbar, {S. H.} and Hagen, {T. C.}",

year = "1981",

month = jan,

doi = "10.1210/endo-108-1-27",

language = "English (US)",

volume = "108",

pages = "27--30",

journal = "Endocrinology",

issn = "0013-7227",

publisher = "The Endocrine Society",

number = "1",

}

TY - JOUR

T1 - Interaction of Age and Thyroid Hormone Status on Na+-K+ ATPase in Rat Renal Cortex and Liver

AU - Gambert, S. R.

AU - Ingbar, S. H.

AU - Hagen, T. C.

PY - 1981/1

Y1 - 1981/1

N2 - Naʻ-Kʻ ATPase was measured in euthyroid, hypothyroid, and hyperthyroid rats aged 6 weeks, 6 months, and 20-24 months. There was a small but significant decline in basal enzyme activity with increasing age in renal cortical tissue. Enzyme activity decreased with hypothyroidism and increased with hyperthyroidism. With increasing age, both the magnitude of the increase resulting from thyrotoxicosis and the absolute enzyme level were significantly less with each increase in the age of the experimental animals. Hypothyroid animals displayed no age-related decline in renal cortical Naʻ-Kʻ ATPase. The decline in Naʻ-Kʻ ATPase in renal cortical tissue is thyroid hormone dependent. In addition, age modifies the response of Naʻʻ ATPase to thyroid hormone.

AB - Naʻ-Kʻ ATPase was measured in euthyroid, hypothyroid, and hyperthyroid rats aged 6 weeks, 6 months, and 20-24 months. There was a small but significant decline in basal enzyme activity with increasing age in renal cortical tissue. Enzyme activity decreased with hypothyroidism and increased with hyperthyroidism. With increasing age, both the magnitude of the increase resulting from thyrotoxicosis and the absolute enzyme level were significantly less with each increase in the age of the experimental animals. Hypothyroid animals displayed no age-related decline in renal cortical Naʻ-Kʻ ATPase. The decline in Naʻ-Kʻ ATPase in renal cortical tissue is thyroid hormone dependent. In addition, age modifies the response of Naʻʻ ATPase to thyroid hormone.

UR - http://www.scopus.com/inward/record.url?scp=0019377669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019377669&partnerID=8YFLogxK

U2 - 10.1210/endo-108-1-27

DO - 10.1210/endo-108-1-27

M3 - Article

C2 - 6257487

AN - SCOPUS:0019377669

SN - 0013-7227

VL - 108

SP - 27

EP - 30

JO - Endocrinology

JF - Endocrinology

IS - 1

ER -

Interaction of Age and Thyroid Hormone Status on Na⁺-K⁺ ATPase in Rat Renal Cortex and Liver

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this