Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B.

Chloe L. Thio, Jacquie Astemborski, Rasmi Thomas, Timothy Mosbruger, Mallory D. Witt, James J. Goedert, Keith Hoots, Cherie Winkler, David L. Thomas, Mary Carrington

Research output: Contribution to journalArticle

Abstract

Recovery from acute hepatitis B virus (HBV) infection occurs in 95% of adult-acquired infections. A 32-bp deletion in CCR5 (CCR5Delta32), which encodes for a nonfunctional receptor, increases the likelihood of recovery. Using 181 subjects with persistent HBV infection and 316 who had recovered, we tested the hypothesis that an epistatic interaction between functional polymorphisms in RANTES (a CCR5 ligand) and CCR5 impacts recovery. Specific models designed to assess individual contributions of compound genotypes demonstrated that the only combination associated with recovery from an HBV infection was RANTES -403A with CCR5Delta32 (odds ratio 0.36, p = 0.02). Because the phenotypic consequence of -403A is reported to be higher levels of RANTES, we propose a model in which excess RANTES in combination with low CCR5 favors recovery from an HBV infection, which will require validation through functional testing.

Original languageEnglish (US)
Pages (from-to)7944-7947
Number of pages4
JournalJournal of Immunology
Volume181
Issue number11
StatePublished - Dec 1 2008

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Chemokine CCL5
Virus Diseases
Hepatitis B
Hepatitis B virus
Odds Ratio
Genotype
Ligands
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thio, C. L., Astemborski, J., Thomas, R., Mosbruger, T., Witt, M. D., Goedert, J. J., ... Carrington, M. (2008). Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. Journal of Immunology, 181(11), 7944-7947.

Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. / Thio, Chloe L.; Astemborski, Jacquie; Thomas, Rasmi; Mosbruger, Timothy; Witt, Mallory D.; Goedert, James J.; Hoots, Keith; Winkler, Cherie; Thomas, David L.; Carrington, Mary.

In: Journal of Immunology, Vol. 181, No. 11, 01.12.2008, p. 7944-7947.

Research output: Contribution to journalArticle

Thio, CL, Astemborski, J, Thomas, R, Mosbruger, T, Witt, MD, Goedert, JJ, Hoots, K, Winkler, C, Thomas, DL & Carrington, M 2008, 'Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B.', Journal of Immunology, vol. 181, no. 11, pp. 7944-7947.
Thio CL, Astemborski J, Thomas R, Mosbruger T, Witt MD, Goedert JJ et al. Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. Journal of Immunology. 2008 Dec 1;181(11):7944-7947.
Thio, Chloe L. ; Astemborski, Jacquie ; Thomas, Rasmi ; Mosbruger, Timothy ; Witt, Mallory D. ; Goedert, James J. ; Hoots, Keith ; Winkler, Cherie ; Thomas, David L. ; Carrington, Mary. / Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. In: Journal of Immunology. 2008 ; Vol. 181, No. 11. pp. 7944-7947.
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