Interaction between BDNF and serotonin: Role in mood disorders

Research output: Contribution to journalReview article

Abstract

Brain-derived neurotrophic factor (BDNF) and serotonin (5- hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes.

Original languageEnglish (US)
Pages (from-to)73-83
Number of pages11
JournalNeuropsychopharmacology
Volume33
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
Mood Disorders
Serotonin
Neuronal Plasticity
Serotonin Plasma Membrane Transport Proteins
Aptitude
Neurogenesis
Serotonin Uptake Inhibitors
Antidepressive Agents
Anxiety
Depression
Gene Expression
Neurons
Genes

Keywords

  • 5-HTT
  • Anxiety
  • Depression
  • p75
  • SSRI
  • TrkB

ASJC Scopus subject areas

  • Pharmacology

Cite this

Interaction between BDNF and serotonin : Role in mood disorders. / Martinowich, Keri; Lu, Bai.

In: Neuropsychopharmacology, Vol. 33, No. 1, 01.2008, p. 73-83.

Research output: Contribution to journalReview article

@article{8f48b8c8cd2241b7929a4977c63f7d7e,
title = "Interaction between BDNF and serotonin: Role in mood disorders",
abstract = "Brain-derived neurotrophic factor (BDNF) and serotonin (5- hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes.",
keywords = "5-HTT, Anxiety, Depression, p75, SSRI, TrkB",
author = "Keri Martinowich and Bai Lu",
year = "2008",
month = "1",
doi = "10.1038/sj.npp.1301571",
language = "English (US)",
volume = "33",
pages = "73--83",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Interaction between BDNF and serotonin

T2 - Role in mood disorders

AU - Martinowich, Keri

AU - Lu, Bai

PY - 2008/1

Y1 - 2008/1

N2 - Brain-derived neurotrophic factor (BDNF) and serotonin (5- hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes.

AB - Brain-derived neurotrophic factor (BDNF) and serotonin (5- hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes.

KW - 5-HTT

KW - Anxiety

KW - Depression

KW - p75

KW - SSRI

KW - TrkB

UR - http://www.scopus.com/inward/record.url?scp=36549042458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36549042458&partnerID=8YFLogxK

U2 - 10.1038/sj.npp.1301571

DO - 10.1038/sj.npp.1301571

M3 - Review article

C2 - 17882234

AN - SCOPUS:36549042458

VL - 33

SP - 73

EP - 83

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 1

ER -