Interaction between BDNF and serotonin: Role in mood disorders

Research output: Contribution to journalReview articlepeer-review

463 Scopus citations


Brain-derived neurotrophic factor (BDNF) and serotonin (5- hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes.

Original languageEnglish (US)
Pages (from-to)73-83
Number of pages11
Issue number1
StatePublished - Jan 2008
Externally publishedYes


  • 5-HTT
  • Anxiety
  • Depression
  • SSRI
  • TrkB
  • p75

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


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