Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy

Fumihiko Tsushima, Sheng Yao, Tahiro Shin, Andrew Flies, Sarah Flies, Haiying Xu, Koji Tamada, Andrew Mark Pardoll, Lieping Chen

Research output: Contribution to journalArticle

Abstract

Although self-reactive T-cell precursors can be eliminated upon recognition of self-antigen presented in the thymus, this central tolerance process is often incomplete, and additional mechanisms are required to prevent autoimmunity. Recent studies indicates that the interaction between B7-H1 and its receptor PD-1 on activated T cells plays an important role in the inhibition of T-cell responses in peripheral organs. Here, we show that, before their exit to the periphery, T cells in lymphoid organs rapidly up-regulate PD-1 upon tolerogen recognition. Ablation of the B7-H1 and PD-1 interaction when T cells are still in lymphoid organs prevents anergy. Furthermore, blockade of B7-H1 and PD-1 interaction could render anergic T cells responsive to antigen. Our results thus reveal previously unappreciated roles of B7-H1 and PD-1 interaction in the control of initiation and reversion of T-cell anergy.

Original languageEnglish (US)
Pages (from-to)180-185
Number of pages6
JournalBlood
Volume110
Issue number1
DOIs
StatePublished - Jul 1 2007

    Fingerprint

ASJC Scopus subject areas

  • Hematology

Cite this

Tsushima, F., Yao, S., Shin, T., Flies, A., Flies, S., Xu, H., Tamada, K., Pardoll, A. M., & Chen, L. (2007). Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood, 110(1), 180-185. https://doi.org/10.1182/blood-2006-11-060087