Inter-organ communication and regulation of beta cell function

Mehboob A. Hussain, Elina Akalestou, Woo jin Song

Research output: Contribution to journalReview article

Abstract

The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell function. To this end, each individual beta cell can be viewed as a sensor of a multitude of stimuli that are integrated to determine the extent of glucose-dependent insulin release. This review discusses recent advances in our understanding of inter-organ communications that regulate beta cell insulin release in response to elevated glucose levels.

Original languageEnglish (US)
Pages (from-to)659-667
Number of pages9
JournalDiabetologia
Volume59
Issue number4
DOIs
StatePublished - Apr 1 2016

Keywords

  • Beta cell
  • Decretin
  • Galanin
  • Ghrelin
  • Incretin
  • Insulin
  • Inter-organ
  • Islet
  • Leptin
  • Muscarinic
  • Review
  • Xenin-25

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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