Inter-organ communication and regulation of beta cell function

Mehboob Hussain, Elina Akalestou, Woo jin Song

Research output: Contribution to journalArticle

Abstract

The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell function. To this end, each individual beta cell can be viewed as a sensor of a multitude of stimuli that are integrated to determine the extent of glucose-dependent insulin release. This review discusses recent advances in our understanding of inter-organ communications that regulate beta cell insulin release in response to elevated glucose levels.

Original languageEnglish (US)
Pages (from-to)659-667
Number of pages9
JournalDiabetologia
Volume59
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Glucose
Insulin
Endocrine Cells
Insulin-Secreting Cells
Islets of Langerhans

Keywords

  • Beta cell
  • Decretin
  • Galanin
  • Ghrelin
  • Incretin
  • Insulin
  • Inter-organ
  • Islet
  • Leptin
  • Muscarinic
  • Review
  • Xenin-25

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Inter-organ communication and regulation of beta cell function. / Hussain, Mehboob; Akalestou, Elina; Song, Woo jin.

In: Diabetologia, Vol. 59, No. 4, 01.04.2016, p. 659-667.

Research output: Contribution to journalArticle

Hussain, Mehboob ; Akalestou, Elina ; Song, Woo jin. / Inter-organ communication and regulation of beta cell function. In: Diabetologia. 2016 ; Vol. 59, No. 4. pp. 659-667.
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