TY - JOUR
T1 - Inter-grader Agreement of the Ocular Staining Score in the Sjögren's International Clinical Collaborative Alliance (SICCA) Registry
AU - Rose-Nussbaumer, Jennifer
AU - Lietman, Thomas M.
AU - Shiboski, Caroline H.
AU - Shiboski, Stephen C.
AU - Bunya, Vatinee Y.
AU - Akpek, Esen K.
AU - Srinivasan, Muthiah
AU - Mascarenhas, Jeena
AU - Massaro-Giordano, Giacomina
AU - McNamara, Nancy A.
AU - Whitcher, John P.
AU - Gaynor, Bruce D.
N1 - Funding Information:
Funding/Support: The research portion of this work is financially supported by contract N01-DE-32636 from the National Institutes of Health, Bethesda Maryland. Individual support is provided by contract #K12-EY-015398 (V.Y.B.) and #K12-EY-017269 (J.R.-N.) from the National Eye Institute, Bethesda Maryland and an unrestricted grant from the Peierls Foundation, Golden Colorado (J.R.-N.). Financial disclosures: Vatinee Y. Bunya has a sponsored research agreement with Amakem, Diepenbeek, Belgium. Financial disclosures: The following authors have no financial disclosures: Jennifer Rose-Nussbaumer, Thomas M. Lietman, Caroline H. Shiboski, Stephen C. Shiboski, Esen K. Akpek, Muthiah Srinivasan, Jeena Mascarenhas, Giacomina Massaro-Giordano, Nancy A. Mcnamara, Johnp.Whitcher, and Bruce D. Gaynor. All authors attest that they meet the current ICMJE criteria for authorship.
Funding Information:
THE RESEARCH PORTION OF THIS WORK IS FINANCIALLY SUPPORTED BY CONTRACT N01-DE-32636 FROM the National Institutes of Health, Bethesda Maryland. Individual support is provided by contract #K12-EY-015398 (V.Y.B.) and #K12-EY-017269 (J.R.-N.) from the National Eye Institute, Bethesda Maryland and an unrestricted grant from the Peierls Foundation, Golden Colorado (J.R.-N.). Vatinee Y. Bunya has a sponsored research agreement with Amakem, Diepenbeek, Belgium. Gaynor. All authors attest that they meet the current ICMJE criteria for authorship. Members of the SICCA research group are available in the following website https://sicca-online.ucsf.edu.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - Purpose To determine the intra-observer and inter-observer reliability of a novel ocular staining score among trained ophthalmologists. Design Reliability analysis within a prospective, observational, multicenter cohort study. Methods Those enrolled in the National Institutes of Health-funded Sjögren's International Collaborative Clinical Alliance (SICCA) who presented for follow-up at the University of California San Francisco, Aravind Eye Hospital, Johns Hopkins University, and the University of Pennsylvania were included. Study participants were graded using the ocular staining score by at least 2 masked SICCA-trained ophthalmologists. The primary outcome for this study was the intraclass correlation coefficient (ICC) for the total ocular staining score. ICCs were also calculated for tear break-up time (TBUT) and conjunctival and corneal staining. Results Total ocular staining score had an ICC of 0.91 for the right eye (95% confidence interval [CI] 0.85-0.96) and 0.90 for the left eye (95% CI 0.83-0.97). Corneal staining (right eye 0.86, 95% CI 0.76-0.93, left eye 0.90, 95% CI 0.81-0.95) and conjunctival staining (right eye 0.87, 95% CI 0.80-0.93, left eye 0.85, 95% CI 0.75-0.93) demonstrated excellent agreement. The ICC for TBUT was slightly lower (right eye 0.77, 95% CI 0.64-0.89; left eye 0.81, 95% CI 0.68-0.90). Conclusions Previous studies have shown that the ocular staining score is correlated with other diagnostic components of Sjögren syndrome. In this study, we demonstrate high reliability in grading among trained ophthalmologists, completing the validation of this test.
AB - Purpose To determine the intra-observer and inter-observer reliability of a novel ocular staining score among trained ophthalmologists. Design Reliability analysis within a prospective, observational, multicenter cohort study. Methods Those enrolled in the National Institutes of Health-funded Sjögren's International Collaborative Clinical Alliance (SICCA) who presented for follow-up at the University of California San Francisco, Aravind Eye Hospital, Johns Hopkins University, and the University of Pennsylvania were included. Study participants were graded using the ocular staining score by at least 2 masked SICCA-trained ophthalmologists. The primary outcome for this study was the intraclass correlation coefficient (ICC) for the total ocular staining score. ICCs were also calculated for tear break-up time (TBUT) and conjunctival and corneal staining. Results Total ocular staining score had an ICC of 0.91 for the right eye (95% confidence interval [CI] 0.85-0.96) and 0.90 for the left eye (95% CI 0.83-0.97). Corneal staining (right eye 0.86, 95% CI 0.76-0.93, left eye 0.90, 95% CI 0.81-0.95) and conjunctival staining (right eye 0.87, 95% CI 0.80-0.93, left eye 0.85, 95% CI 0.75-0.93) demonstrated excellent agreement. The ICC for TBUT was slightly lower (right eye 0.77, 95% CI 0.64-0.89; left eye 0.81, 95% CI 0.68-0.90). Conclusions Previous studies have shown that the ocular staining score is correlated with other diagnostic components of Sjögren syndrome. In this study, we demonstrate high reliability in grading among trained ophthalmologists, completing the validation of this test.
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U2 - 10.1016/j.ajo.2015.08.021
DO - 10.1016/j.ajo.2015.08.021
M3 - Article
C2 - 26302236
AN - SCOPUS:84941242414
SN - 0002-9394
VL - 160
SP - 1150-1153.e3
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -