TY - JOUR
T1 - Intentional weight loss and dose reductions of antihypertensive medications
T2 - A retrospective cohort study
AU - Shantha, Ghanshyam Palamaner Subash
AU - Kumar, Anita Ashok
AU - Kahan, Scott
AU - Cheah, Sang Yun
AU - Cheskin, Lawrence J.
N1 - Publisher Copyright:
© 2013 S. Karger AG, Basel.
PY - 2013/4/16
Y1 - 2013/4/16
N2 - Background: Though it is well known that weight loss tends to decrease blood pressure, the quantitative association between the magnitude of weight loss and the effect on the need for antihypertensive medications is not well studied. We analyzed this association among overweight and obese attendees at two outpatient weight management centers. Methods: Case records of patients with a body mass index >25 at baseline were analyzed. The weight loss intervention consisted of a calorie-restricted diet (1,000 kcal/day deficit), a behavior modification plan, and a plan for increasing physical activity. Results: The study cohort consisted of 100 participants, and the mean follow-up period was 15 ± 3.5 months. Significant weight loss (12.2 ± 3.4 kg) and systolic/diastolic blood pressure reductions (9.1/6.3 mm Hg) were observed by study exit. For 5, 10, and 15% weight loss, respectively, 3, 39, and 39% of the patients achieved at least 1 discontinuation of any antihypertensive medication, and 8, 42, and 21 dose reductions were achieved. Dose reductions or discontinuations occurred in all classes of antihypertensive medications with similar magnitudes of weight loss. Conclusions: Intentional weight loss can potentially result in dose reductions/discontinuations of antihypertensive medications. Our results should be validated with data from larger randomized controlled studies and may help to inform the conduct of a systematic review of prior randomized controlled trials that contain data on medication changes accompanying weight loss.
AB - Background: Though it is well known that weight loss tends to decrease blood pressure, the quantitative association between the magnitude of weight loss and the effect on the need for antihypertensive medications is not well studied. We analyzed this association among overweight and obese attendees at two outpatient weight management centers. Methods: Case records of patients with a body mass index >25 at baseline were analyzed. The weight loss intervention consisted of a calorie-restricted diet (1,000 kcal/day deficit), a behavior modification plan, and a plan for increasing physical activity. Results: The study cohort consisted of 100 participants, and the mean follow-up period was 15 ± 3.5 months. Significant weight loss (12.2 ± 3.4 kg) and systolic/diastolic blood pressure reductions (9.1/6.3 mm Hg) were observed by study exit. For 5, 10, and 15% weight loss, respectively, 3, 39, and 39% of the patients achieved at least 1 discontinuation of any antihypertensive medication, and 8, 42, and 21 dose reductions were achieved. Dose reductions or discontinuations occurred in all classes of antihypertensive medications with similar magnitudes of weight loss. Conclusions: Intentional weight loss can potentially result in dose reductions/discontinuations of antihypertensive medications. Our results should be validated with data from larger randomized controlled studies and may help to inform the conduct of a systematic review of prior randomized controlled trials that contain data on medication changes accompanying weight loss.
KW - Antihypertensive agents
KW - Blood pressure
KW - Hypertension
KW - Obesity
KW - Weight loss
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U2 - 10.1159/000347048
DO - 10.1159/000347048
M3 - Article
C2 - 23946722
AN - SCOPUS:84927745701
SN - 1664-3828
VL - 3
SP - 17
EP - 25
JO - CardioRenal Medicine
JF - CardioRenal Medicine
IS - 1
ER -