Intensity of immunosuppressive therapy and the incidence of Pneumocystis carinii pneumonitis

W. T. Hughes, S. Feldman, R. J A Aur, M. S. Verzosa, H. O. Hustu, J. V. Simone

Research output: Contribution to journalArticle

Abstract

A series of 149 children with acute lymphocytic leukemia treated according to a prospective protocol was randomized after induction of remission and central nervous system (CNS) irradiation to receive maintenance chemotherapy with 1, 2, 3, or 4 chemotherapy agents. The incidence of P. carinii pneumonitis (PCP) was 5.0, 2.3, 2.2, and 22.4%, respectively, during the period of maintenance therapy. An additional 31 patients enrolled in the same study were placed in special categories to receive three drugs for maintenance plus supplemental chemotherapy or irradiation because of CNS leukemia on admission, remission failure, mediastinal mass, or generalized lymphosarcoma without bone marrow involvement. The incidences of PCP in these groups were 16.7, 30.0, 35.7, and 0%, respectively, during the period of maintenance therapy.

Original languageEnglish (US)
Pages (from-to)2004-2009
Number of pages6
JournalCancer
Volume36
Issue number6
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Hughes, W. T., Feldman, S., Aur, R. J. A., Verzosa, M. S., Hustu, H. O., & Simone, J. V. (1975). Intensity of immunosuppressive therapy and the incidence of Pneumocystis carinii pneumonitis. Cancer, 36(6), 2004-2009.