Intensity fluctuation spectroscopy monitors contractile activation in "resting" cardiac muscle

Donald L. Lappé, Edward G. Lakatta

Research output: Contribution to journalArticlepeer-review

Abstract

Intensity fluctuations in a laser beam scattered by nonbeating isolated rat cardiac muscle varied directly with the calcium concentration in the bathing fluid. The steady-state level of these fluctuations varied directly with calcium-dependent force suggesting that the intensity fluctuations reflect an interaction of calcium ions with the myofilaments. The demonstration that both a portion of resting force and the frequency of intensity fluctuations vary directly with calcium even in quiescent conditions indicates that some contractile activation is present in the resting muscle.

Original languageEnglish (US)
Pages (from-to)1369-1371
Number of pages3
JournalScience
Volume207
Issue number4437
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • General

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