TY - JOUR
T1 - Intensified short symptom screening program for dengue infection during pregnancy, India
AU - Naik, Shilpa
AU - Robinson, Matthew L.
AU - Alexander, Mallika
AU - Chandanwale, Ajay
AU - Sambarey, Pradip
AU - Kinikar, Aarti
AU - Bharadwaj, Renu
AU - Sapkal, Gajanan N.
AU - Chebrolu, Puja
AU - Deshpande, Prasad
AU - Kulkarni, Vandana
AU - Nimkar, Smita
AU - Mave, Vidya
AU - Gupta, Amita
AU - Mathad, Jyoti
N1 - Funding Information:
This study was supported, in part, by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (grants UM1AI069465 and R01HD081929 to A.G., grant K23AI129854 to J.M., grant UM1AI104681 to M.L.R., and grant D43TW009574 to R.B.), as well as the Kellen Foundation, the Ujala Foundation, the Gilead Foundation, and the Wyncote Foundation.
Funding Information:
We thank the Department of Obstetrics and Gynecology at Byramjee Jeejeebhoy Medical College and Sassoon Hospital and Pradip Awate for assistance during the study and the US Centers for Disease Control and Prevention for providing the Trioplex assay. This study was supported, in part, by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (grants UM1AI069465 and R01HD081929 to A.G., grant K23AI129854 to J.M., grant UM1AI104681 to M.L.R., and grant D43TW009574 to R.B.), as well as the Kellen Foundation, the Ujala Foundation, the Gilead Foundation, and the Wyncote Foundation.
Publisher Copyright:
© 2020 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2020/4
Y1 - 2020/4
N2 - Mosquitoborne diseases (e.g., malaria, dengue, and chikungunya) are endemic to India and pose diagnostic challenges during pregnancy. We evaluated an intensified short symptom screening program in India to diagnose dengue during pregnancy. During October 2017–January 2018, we screened pregnant women during antenatal surveillance for symptoms of mosquitoborne diseases (fever only, fever with conjunctivitis, fever with rash, or all 3 symptoms) within the previous 15 days. Of 5,843 pregnant women screened, 52 were enrolled and tested for dengue, chikungunya, and Zika viruses by using a Trioplex real-time reverse transcription PCR. Of 49 who had complete results, 7 (14%) were dengue positive. Of these, ocular pain was seen in 4 (57%) and conjunctivitis in 7 (100%). Intensified symptom screening using conjunctivitis, in addition to rash, in pregnant women with fever might improve dengue case detection and can be included in routine symptom screening during pregnancy.
AB - Mosquitoborne diseases (e.g., malaria, dengue, and chikungunya) are endemic to India and pose diagnostic challenges during pregnancy. We evaluated an intensified short symptom screening program in India to diagnose dengue during pregnancy. During October 2017–January 2018, we screened pregnant women during antenatal surveillance for symptoms of mosquitoborne diseases (fever only, fever with conjunctivitis, fever with rash, or all 3 symptoms) within the previous 15 days. Of 5,843 pregnant women screened, 52 were enrolled and tested for dengue, chikungunya, and Zika viruses by using a Trioplex real-time reverse transcription PCR. Of 49 who had complete results, 7 (14%) were dengue positive. Of these, ocular pain was seen in 4 (57%) and conjunctivitis in 7 (100%). Intensified symptom screening using conjunctivitis, in addition to rash, in pregnant women with fever might improve dengue case detection and can be included in routine symptom screening during pregnancy.
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UR - http://www.scopus.com/inward/citedby.url?scp=85081988777&partnerID=8YFLogxK
U2 - 10.3201/eid2604.191476
DO - 10.3201/eid2604.191476
M3 - Article
C2 - 32186485
AN - SCOPUS:85081988777
SN - 1080-6040
VL - 26
SP - 738
EP - 743
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 4
ER -