Integrins and bone metastasis: Integrating tumor cell and stromal cell interactions

Jochen G. Schneider, Sarah Amend, Katherine N. Weilbaecher

Research output: Contribution to journalReview article

Abstract

Integrins on both tumor cells and the supporting host stromal cells in bone (osteoclasts, new blood vessels, inflammatory cells, platelets and bone marrow stromal cells) play key roles in enhancing bone metastasis. Tumor cells localize to specific tissues through integrin-mediated contacts with extracellular matrix and stromal cells. Integrin expression and signaling are perturbed in cancer cells, allowing them to "escape" from cell-cell and cell-matrix tethers, invade, migrate and colonize within new tissues and matrices. Integrin signaling through αvβ3 and VLA-4 on tumor cells can promote tumor metastasis to and proliferation in the bone microenvironment. Osteoclast (OC) mediated bone resorption is a critical component of bone metastasis and can promote tumor growth in bone and αvβ3 integrins are critical to OC function and development. Tumors in the bone microenvironment can recruit new blood vessel formation, platelets, pro-tumor immune cells and bone marrow stromal cells that promote tumor growth and invasion in bone. Integrins and their ligands play critical roles in platelet aggregation (αvβ3 and αIIbβ3), hematopoietic cell mobilization (VLA-4 and osteopontin), neoangiogenesis (αvβ3, αvβ5, α6β4, and β1 integrin) and stromal function (osteopontin and VLA-4). Integrins are involved in the pathogenesis of bone metastasis at many levels and further study to define integrin dysregulation by cancer will yield new therapeutic targets for the prevention and treatment of bone metastasis.

Original languageEnglish (US)
Pages (from-to)54-65
Number of pages12
JournalBone
Volume48
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Fingerprint

Stromal Cells
Integrins
Cell Communication
Neoplasm Metastasis
Bone and Bones
Neoplasms
Integrin alpha4beta1
Osteoclasts
Osteopontin
Mesenchymal Stromal Cells
Blood Vessels
Blood Platelets
Bone Development
Bone Resorption
Platelet Aggregation
Extracellular Matrix
Ligands

Keywords

  • Bone metastasis
  • Cancer therapy
  • Endothelium
  • Integrins
  • Osteoclasts
  • Platelets

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Cite this

Integrins and bone metastasis : Integrating tumor cell and stromal cell interactions. / Schneider, Jochen G.; Amend, Sarah; Weilbaecher, Katherine N.

In: Bone, Vol. 48, No. 1, 01.01.2011, p. 54-65.

Research output: Contribution to journalReview article

Schneider, Jochen G. ; Amend, Sarah ; Weilbaecher, Katherine N. / Integrins and bone metastasis : Integrating tumor cell and stromal cell interactions. In: Bone. 2011 ; Vol. 48, No. 1. pp. 54-65.
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