Integrative modeling of cardiac arrhythmia: Relating gene expression to cell and tissue function

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development and analysis of biophysically and anatomically detailed computational models of physiological systems is beginning to provide an important tool for relating changes in gene expression to changes in biological function at the levels of cell and tissue in both health and disease. Computational modeling demonstrates that the altered expression of genes coding proteins involved in intracellular Ca2+ handling plays a key role in prolonging the action potential duration (APD) and increasing the likelihood of early after-depolarization known to occur in failing myocytes and may trigger reentrant arrhythmias at the level of the whole heart.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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