Integrative mathematical modeling for analysis of microcirculatory function

Adam Kapela, Anastasios Bezerianos, Nikolaos Tsoukias

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The microcirculatory vascular tone and the regional blood flow are regulated by an elaborate network of intracellular and extracellular signaling pathways with multiple feedback control loops. This complicates interpretation of experimental data and limits our ability to design appropriate interventions. Mathematical modeling offers a systematic approach for system and data analysis and for guiding new experimentation. We describe here our efforts to model signal transduction events involved in the regulation of blood flow and integrate mechanisms at the cellular level to describe function at the multicellular/wholevessel level. The model provides a) a working database of rat mesenteric endothelial and smooth muscle physiology where newly acquired experimental information on cell electrophysiology and signal transduction can be incorporated, and b) a tool that will assist investigations on the regulation of vascular resistance in health and disease. An example of model application to the study of the pathogenesis of salt-sensitive hypertension is illustrated.

Original languageEnglish (US)
Title of host publicationBiological and Medical Data Analysis - 7th International Symposium, ISBMDA 2006, Proceedings
PublisherSpringer Verlag
Pages161-171
Number of pages11
ISBN (Print)3540680632, 9783540680635
DOIs
StatePublished - Jan 1 2006
Event7th International Symposium on Biological and Medical Data Analysis, ISBMDA 2006 - Thessaloniki, Greece
Duration: Dec 7 2006Dec 8 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4345 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other7th International Symposium on Biological and Medical Data Analysis, ISBMDA 2006
CountryGreece
CityThessaloniki
Period12/7/0612/8/06

Keywords

  • Calcium dynamics
  • Integrative computational physiology
  • Microcirculation
  • Vascular system

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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