TY - JOUR
T1 - Integrative action of receptor mosaics
T2 - Relevance of receptor topology and allosteric modulators
AU - Francesco, Agnati Luigi
AU - Diego, Guidolin
AU - Susanna, Genedani
AU - Giuseppina, Leo
AU - Amina, Woods S.
AU - Sergi, Ferrè
AU - Rafael, Franco
AU - Kjell, Fuxe
PY - 2008/11
Y1 - 2008/11
N2 - After a definition of the receptor mosaic (RM, high order heteromer or homomer) concept, this study analyzes some relevant theoretical aspects related to receptor-receptor interactions (RRIs). In particular, the possible influence of the plasma membrane microdomain on RM integrative functions are discussed. Furthermore, a possible mathematical approach may identify the RM topologies [i.e., the spatial arrangements the receptors (tesserae of the mosaic) can assume within the RM assembly]. Finally, data are presented on homocysteine possible biasing action on the well-characterized heterodimer/receptor mosaic formed by adenosine A2A and dopamine D2 receptors. We discuss how these findings can lead to a new possible approach for developing drugs for the treatment of certain neuropsychiatric disorders.
AB - After a definition of the receptor mosaic (RM, high order heteromer or homomer) concept, this study analyzes some relevant theoretical aspects related to receptor-receptor interactions (RRIs). In particular, the possible influence of the plasma membrane microdomain on RM integrative functions are discussed. Furthermore, a possible mathematical approach may identify the RM topologies [i.e., the spatial arrangements the receptors (tesserae of the mosaic) can assume within the RM assembly]. Finally, data are presented on homocysteine possible biasing action on the well-characterized heterodimer/receptor mosaic formed by adenosine A2A and dopamine D2 receptors. We discuss how these findings can lead to a new possible approach for developing drugs for the treatment of certain neuropsychiatric disorders.
KW - Allosteric modulators
KW - Homocysteine
KW - Receptor mosaics
KW - Receptor topology
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U2 - 10.1080/10799890802590420
DO - 10.1080/10799890802590420
M3 - Article
C2 - 19096975
AN - SCOPUS:58149085559
SN - 1079-9893
VL - 28
SP - 543
EP - 565
JO - Journal of Receptor and Signal Transduction Research
JF - Journal of Receptor and Signal Transduction Research
IS - 6
ER -