Integrative action of receptor mosaics: Relevance of receptor topology and allosteric modulators

Agnati Luigi Francesco, Guidolin Diego, Genedani Susanna, Leo Giuseppina, Woods S. Amina, Ferrè Sergi, Franco Rafael, Fuxe Kjell

Research output: Contribution to journalArticle

Abstract

After a definition of the receptor mosaic (RM, high order heteromer or homomer) concept, this study analyzes some relevant theoretical aspects related to receptor-receptor interactions (RRIs). In particular, the possible influence of the plasma membrane microdomain on RM integrative functions are discussed. Furthermore, a possible mathematical approach may identify the RM topologies [i.e., the spatial arrangements the receptors (tesserae of the mosaic) can assume within the RM assembly]. Finally, data are presented on homocysteine possible biasing action on the well-characterized heterodimer/receptor mosaic formed by adenosine A2A and dopamine D2 receptors. We discuss how these findings can lead to a new possible approach for developing drugs for the treatment of certain neuropsychiatric disorders.

Original languageEnglish (US)
Pages (from-to)543-565
Number of pages23
JournalJournal of Receptor and Signal Transduction Research
Volume28
Issue number6
DOIs
StatePublished - Nov 2008
Externally publishedYes

Keywords

  • Allosteric modulators
  • Homocysteine
  • Receptor mosaics
  • Receptor topology

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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  • Cite this

    Francesco, A. L., Diego, G., Susanna, G., Giuseppina, L., Amina, W. S., Sergi, F., Rafael, F., & Kjell, F. (2008). Integrative action of receptor mosaics: Relevance of receptor topology and allosteric modulators. Journal of Receptor and Signal Transduction Research, 28(6), 543-565. https://doi.org/10.1080/10799890802590420