Integration of vitamin A supplementation with the Expanded Programme on Immunization: Lack of impact on morbidity or infant growth

Rd Semba, Z. Munasir, A. Akib, G. Melikian, D. Permaesih, S. Marituti

Research output: Contribution to journalArticlepeer-review

Abstract

Vitamin A deficiency is associated with increased morbidity and mortality from diarrheal disease, measles, and malaria. It has been proposed that vitamin A supplementation could be linked with childhood immunization programs to improve child health. We conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the impact of linking vitamin A supplementation with the Expanded Programme on Immunization on morbidity and child growth. In West Java, Indonesia, 467 six-week-old infants were randomized to receive 7.5 mg retinol equivalent (RE), 15 mg RE, or placebo with childhood immunization contacts at 6, 10, and 14 wks and 9 mo of age. Child growth was assessed through anthropometry, and morbidity histories were obtained. Vitamin A supplementation had no apparent impact upon linear or ponderal growth or infectious disease morbidity in the first 15 mo of age when integrated with the Expanded Programme on Immunization. Conclusion: Although improving vitamin A nutriture is of general importance in reducing diarrheal and measles morbidity and mortality in developing countries, this clinical trial showed no apparent benefit of vitamin A capsules for infant health when given through childhood immunization programs.

Original languageEnglish (US)
Pages (from-to)1107-1111
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Volume90
Issue number10
DOIs
StatePublished - 2001

Keywords

  • Diarrhea
  • Growth
  • Immunization
  • Infants
  • Vitamin A

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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