TY - JOUR
T1 - Integration of bilateral whisker stimuli in rats
T2 - Role of the whisker barrel cortices
AU - Shuler, Marshall G.
AU - Krupa, David J.
AU - Nicoleis, Miguel A.L.
PY - 2002
Y1 - 2002
N2 - Recently, we demonstrated that neural responses within the whisker region of the primary somatosensory cortex (Slw) of rats are profoundly influenced by the spatiotemporal attributes of ipsilateral, as well as contralateral, whisker stimuli. As inactivation of one Slw eliminates in the intact Slw both ipsilaterally evoked responses and the influence of ipsilateral stimulation on contralaterally evoked activity, we proposed that interhemispheric interactions between the Slws may be important for integrating bilateral whisker information. To test whether rats can recognize the bilateral nature of a whisker stimulus, we developed a tactile discrimination task that required rats to conjointly determine distances to a left and a right discriminandum as equidistant or non-equidistant using only their facial whiskers. All rats trained in this task achieved performance levels indicative of an ability to integrate bilateral whisker information. Testing during unilateral, as well as bilateral, inactivation of the Slws indicated that rats rely on both Slws for detecting the bilateral nature of a whisker stimulus. Rats were unable to perform the task without both sets of whiskers, a fact that indicates that the whiskers (and not other modalities) were used to perform this task. The findings presented here indicate that rats can solve a task that requires the conjoint detection of left and right whisker-mediated distance information and implicate the Slws as central to this ability.
AB - Recently, we demonstrated that neural responses within the whisker region of the primary somatosensory cortex (Slw) of rats are profoundly influenced by the spatiotemporal attributes of ipsilateral, as well as contralateral, whisker stimuli. As inactivation of one Slw eliminates in the intact Slw both ipsilaterally evoked responses and the influence of ipsilateral stimulation on contralaterally evoked activity, we proposed that interhemispheric interactions between the Slws may be important for integrating bilateral whisker information. To test whether rats can recognize the bilateral nature of a whisker stimulus, we developed a tactile discrimination task that required rats to conjointly determine distances to a left and a right discriminandum as equidistant or non-equidistant using only their facial whiskers. All rats trained in this task achieved performance levels indicative of an ability to integrate bilateral whisker information. Testing during unilateral, as well as bilateral, inactivation of the Slws indicated that rats rely on both Slws for detecting the bilateral nature of a whisker stimulus. Rats were unable to perform the task without both sets of whiskers, a fact that indicates that the whiskers (and not other modalities) were used to perform this task. The findings presented here indicate that rats can solve a task that requires the conjoint detection of left and right whisker-mediated distance information and implicate the Slws as central to this ability.
UR - http://www.scopus.com/inward/record.url?scp=0036133092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036133092&partnerID=8YFLogxK
U2 - 10.1093/cercor/12.1.86
DO - 10.1093/cercor/12.1.86
M3 - Article
C2 - 11734535
AN - SCOPUS:0036133092
SN - 1047-3211
VL - 12
SP - 86
EP - 97
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 1
ER -