TY - GEN
T1 - Integration of angiogenesis modules at multiple scales
T2 - 14th Pacific Symposium on Biocomputing, PSB 2009
AU - Qutub, Amina A.
AU - Liu, Gang
AU - Vempati, Prakash
AU - Popel, Aleksander S.
PY - 2009
Y1 - 2009
N2 - Multiscale modeling has emerged as a powerful approach to interpret and capitalize on the biological complexity underlying blood vessel growth. We present a multiscale model of angiogenesis that heralds the start of a large scale initiative to integrate related biological models. The goal of the integrative project is to better understand underlying biological mechanisms from the molecular level up through the organ systems level, and test new therapeutic strategies. Model methodology includes ordinary and partial differential equations, stochastic models, complex logical rules, and agent-based architectures. Current modules represent blood flow, oxygen transport, growth factor distribution and signaling, cell sensing, cell movement and cell proliferation. Challenges of integration lie in connecting modules that are diversely designed, seamlessly coordinating feedback, and representing spatial and time scales from ligand-receptor interactions and intracellular signaling, to cell-level movement and cell-matrix interactions, to vessel branching and capillary network formation, to tissue level characteristics, to organ system response. We briefly introduce the individual modules, discuss our approach to integration, present initial results from the coordination of modules, and propose solutions to some critical issues facing angiogenesis multiscale modeling and integration.
AB - Multiscale modeling has emerged as a powerful approach to interpret and capitalize on the biological complexity underlying blood vessel growth. We present a multiscale model of angiogenesis that heralds the start of a large scale initiative to integrate related biological models. The goal of the integrative project is to better understand underlying biological mechanisms from the molecular level up through the organ systems level, and test new therapeutic strategies. Model methodology includes ordinary and partial differential equations, stochastic models, complex logical rules, and agent-based architectures. Current modules represent blood flow, oxygen transport, growth factor distribution and signaling, cell sensing, cell movement and cell proliferation. Challenges of integration lie in connecting modules that are diversely designed, seamlessly coordinating feedback, and representing spatial and time scales from ligand-receptor interactions and intracellular signaling, to cell-level movement and cell-matrix interactions, to vessel branching and capillary network formation, to tissue level characteristics, to organ system response. We briefly introduce the individual modules, discuss our approach to integration, present initial results from the coordination of modules, and propose solutions to some critical issues facing angiogenesis multiscale modeling and integration.
UR - http://www.scopus.com/inward/record.url?scp=61949437319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=61949437319&partnerID=8YFLogxK
M3 - Conference contribution
C2 - 19209711
AN - SCOPUS:61949437319
SN - 9812836926
SN - 9789812836922
T3 - Pacific Symposium on Biocomputing 2009, PSB 2009
SP - 316
EP - 327
BT - Pacific Symposium on Biocomputing 2009, PSB 2009
Y2 - 5 January 2009 through 9 January 2009
ER -