Integration of angiogenesis modules at multiple scales: From molecular to tissue

Amina A. Qutub, Gang Liu, Prakash Vempati, Aleksander S. Popel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Multiscale modeling has emerged as a powerful approach to interpret and capitalize on the biological complexity underlying blood vessel growth. We present a multiscale model of angiogenesis that heralds the start of a large scale initiative to integrate related biological models. The goal of the integrative project is to better understand underlying biological mechanisms from the molecular level up through the organ systems level, and test new therapeutic strategies. Model methodology includes ordinary and partial differential equations, stochastic models, complex logical rules, and agent-based architectures. Current modules represent blood flow, oxygen transport, growth factor distribution and signaling, cell sensing, cell movement and cell proliferation. Challenges of integration lie in connecting modules that are diversely designed, seamlessly coordinating feedback, and representing spatial and time scales from ligand-receptor interactions and intracellular signaling, to cell-level movement and cell-matrix interactions, to vessel branching and capillary network formation, to tissue level characteristics, to organ system response. We briefly introduce the individual modules, discuss our approach to integration, present initial results from the coordination of modules, and propose solutions to some critical issues facing angiogenesis multiscale modeling and integration.

Original languageEnglish (US)
Title of host publicationPacific Symposium on Biocomputing 2009, PSB 2009
Pages316-327
Number of pages12
StatePublished - Dec 1 2009
Event14th Pacific Symposium on Biocomputing, PSB 2009 - Kohala Coast, HI, United States
Duration: Jan 5 2009Jan 9 2009

Publication series

NamePacific Symposium on Biocomputing 2009, PSB 2009

Other

Other14th Pacific Symposium on Biocomputing, PSB 2009
CountryUnited States
CityKohala Coast, HI
Period1/5/091/9/09

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Biomedical Engineering
  • Medicine(all)

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  • Cite this

    Qutub, A. A., Liu, G., Vempati, P., & Popel, A. S. (2009). Integration of angiogenesis modules at multiple scales: From molecular to tissue. In Pacific Symposium on Biocomputing 2009, PSB 2009 (pp. 316-327). (Pacific Symposium on Biocomputing 2009, PSB 2009).