@article{65d0f4d452624f1d89b39ad8675962e2,
title = "Integrating Frailty Research into the Medical Specialties—Report from a U13 Conference",
abstract = "Although the field of frailty research has expanded rapidly, it is still a nascent concept within the clinical specialties. Frailty, conceptualized as greater vulnerability to stressors because of significant depletion of physiological reserves, predicts poorer outcomes in several medical specialties, including cardiology, human immunodeficiency virus care, and nephrology, and in the behavioral and social sciences. Lack of a consensus definition, proliferation of measurement tools, inadequate understanding of the biology of frailty, and lack of validated clinical algorithms for frail individuals hinders incorporation of frailty assessment and frailty research into the specialties. In 2015, the American Geriatrics Society, the National Institute on Aging (NIA), and the Alliance for Academic Internal Medicine held a conference for awardees of the NIA-sponsored Grants for Early Medical/Surgical Specialists Transition into Aging Research program to review the current state of knowledge regarding frailty in the subspecialties and to highlight examples of integrating frailty research into the medical specialties. Research questions to advance frailty research into specialty medicine are proposed.",
keywords = "biologic mechanisms, clinical manifestations, frailty, measurement, medical specialties",
author = "Jeremy Walston and Robinson, {Thomas N.} and Susan Zieman and Frances McFarland and Carpenter, {Christopher R.} and Althoff, {Keri N.} and Andrew, {Melissa K.} and Blaum, {Caroline S.} and Brown, {Patrick J.} and Brian Buta and Ely, {E. Wesley} and Luigi Ferrucci and High, {Kevin P.} and Kritchevsky, {Stephen B.} and Kenneth Rockwood and Schmader, {Kenneth E.} and Felipe Sierra and Sink, {Kaycee M.} and Ravi Varadhan and Arti Hurria",
note = "Funding Information: Conflict of Interest: AH is funded by NIH (U13 AG048721, R01 AG037037, R01 CA172119, R25 CA183723), the Breast Cancer Research Foundation, the UniHealth Foundation, and the Hearst Foundation; serves as a consultant for Boehringer Ingelheim Pharmaceuticals, Carevive, Sanofi, Pierian Biosciences, and GTx, Inc.; and is a member of the American Society of Clinical Oncology Board of Directors and International Society of Geriatric Oncology Board. CRC serves as co-principal investigator of the U13 award supporting the GEMSSTAR conference, serving as co-organizer; is Deputy Editor-in-Chief of Academic Emergency Medicine and Editorial Board Member of the Journal of the American Geriatrics Society; and is a faculty member of the Continuing Medical Education product Emergency Medical Abstracts. KNA received funding from the National Institute of Allergy and Infectious Diseases and NIH (K01 AI093197) and has served as a medical advisory board member for Gilead Sciences, Inc. MKA has grant funding in the form of collaborative research agreements from GSK and Pfizer (with the Canadian Institutes of Health Research and the Public Health Agency of Canada) and from Sanofi Pasteur (with the Canadian Frailty Network) and occasionally provides clinical linguistic consulting services to ICON language services. BB is funded by the Johns Hopkins University Claude D. Pepper Older Americans Independence Center, National Institute on Aging (P30AG021334). EWE is funded by NIA and the Department of Veterans Affairs and receives honoraria from Orion, Pfizer, and Abbott. KPH receives royalties from McGraw-Hill as the Associate Editor of Hazzard's Geriatric Medicine. KR receives grant funding from the Canadian Institutes of Health Research; received honoraria from Nutricia for attending an ad board meeting in 2015; spoke at a speakers' forum for Nutricia in 2015; is the founder of DGI Clinical, which conducts outcome measurement and data analytics for pharmaceutical companies; and receives royalties that are assigned to Dalhousie University. KES was supported by NIA P30 AG028716. FS is involved in grants management at NIH and was a speaker at the speaker forum for the U13 conference. KMS receives grant funding from NIH and as a site private investigator of industry-sponsored trials by Biogen, vTv Therapeutics, Lilly, Toyama, and Navidea Biopharmaceuticals. RV receives grant funding from the Johns Hopkins University Claude D. Pepper Older Americans Independence Center, National Institute on Aging (P30AG021334), Johns Hopkins University Claude D. Pepper Older Americans Independence Center, National Institute on Aging (P30AG021334), and supports the frailty-related research of BB, RV, and JW. Author Contributions: JW, TNR, SZ, CRC, KNA, MKA, CSB, PJB, EWE, LF, KPH, SBK, KES, FS, KMS, AH: Study concept and design. KA, PJB, EWE, KES, KMS, RV, AH: Analysis and interpretation of data. JW, TNR, SZ, FM, KA, PJB, BB, KPH, SBK, KR, LF, KES, KMS, RV, AH: Preparation of manuscript. Sponsor's Role: Funding was provided by the National Institutes of Health. The information and views in this manuscript do not necessarily reflect those of the National Institute on Aging and/or the National Institutes of Health. Funding Information: With this background in mind, a conference, sponsored by an NIA collaborative conference grant to the American Geriatrics Society with additional support from the Alliance for Academic Internal Medicine and the John A. Hartford Foundation, was held on March 2–3, 2015, in Bethesda, Maryland for NIA Grants for Early Medical/Surgical Specialists Transition into Aging Research11 awardees entitled Integrating Frailty Research into Specialty Research. The conference aimed to advance the field of frailty research in the specialties by highlighting examples of how frailty research has been used in specialties over the past decade. The ultimate goal of this conference was to help stimulate frailty research programs in many disciplines to develop better care for vulnerable older adults in a variety of clinical settings. This article summarizes the integration of the concept of frailty into medical specialty research; a summary of the integration of the concept of frailty into surgical specialties research from this conference has been published.12 Funding Information: Sponsor{\textquoteright}s Role: Funding was provided by the National Institutes of Health. The information and views in this manuscript do not necessarily reflect those of the National Institute on Aging and/or the National Institutes of Health. Publisher Copyright: {\textcopyright} 2017, Copyright the Authors Journal compilation {\textcopyright} 2017, The American Geriatrics Society",
year = "2017",
month = oct,
doi = "10.1111/jgs.14902",
language = "English (US)",
volume = "65",
pages = "2134--2139",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "10",
}