Integrating diverse genomic data using gene sets

Svitlana Tyekucheva, Luigi Marchionni, Rachel Karchin, Giovanni Parmigiani

Research output: Contribution to journalArticle

Abstract

We introduce and evaluate data analysis methods to interpret simultaneous measurement of multiple genomic features made on the same biological samples. Our tools use gene sets to provide an interpretable common scale for diverse genomic information. We show we can detect genetic effects, although they may act through different mechanisms in different samples, and show we can discover and validate important disease-related gene sets that would not be discovered by analyzing each data type individually.

Original languageEnglish (US)
Article numberR105
JournalGenome biology
Volume12
Issue number10
DOIs
StatePublished - Oct 21 2011

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Integrating diverse genomic data using gene sets'. Together they form a unique fingerprint.

  • Cite this