Integrated treatment modality of cathodal-transcranial direct current stimulation with peripheral sensory stimulation affords neuroprotection in a rat stroke model

Yu Hang Liu, Su Jing Chan, Han Chi Pan, Aishwarya Bandla, Nicolas K.K. King, Peter Tsun Hon Wong, You Yin Chen, Wai Hoe Ng, Nitish V Thakor, Lun De Liao

Research output: Contribution to journalArticle

Abstract

Cathodal-transcranial direct current stimulation induces therapeutic effects in animal ischemia models by preventing the expansion of ischemic injury during the hyperacute phase of ischemia. However, its efficacy is limited by an accompanying decrease in cerebral blood flow. On the other hand, peripheral sensory stimulation can increase blood flow to specific brain areas resulting in rescue of neurovascular functions from ischemic damage. Therefore, the two modalities appear to complement each other to form an integrated treatment modality. Our results showed that hemodynamics was improved in a photothrombotic ischemia model, as cerebral blood volume and hemoglobin oxygen saturation (SO2) recovered to 71% and 76% of the baseline values, respectively. Furthermore, neural activities, including somatosensory-evoked potentials (110% increase), the alpha-to-delta ratio (27% increase), and the (delta+theta)/(alpha+beta) ratio (27% decrease), were also restored. Infarct volume was reduced by 50% with a 2-fold preservation in the number of neurons and a 6-fold reduction in the number of active microglia in the infarct region compared with the untreated group. Grip strength was also better preserved (28% higher) compared with the untreated group. Overall, this nonpharmacological, nonintrusive approach could be prospectively developed into a clinical treatment modality.

Original languageEnglish (US)
Article number045002
JournalNeurophotonics
Volume4
Issue number4
DOIs
StatePublished - Oct 1 2017

Keywords

  • electrocorticography
  • functional photoacoustic microscopy
  • neurovascular function
  • peripheral sensory stimulation
  • photothrombotic ischemia
  • transcranial direct current stimulation

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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