Integrated multimodal imaging of dynamic bone-tumor alterations associated with metastatic prostate cancer

Jean Christophe Brisset, Benjamin A. Hoff, Thomas L. Chenevert, Jon A. Jacobson, Jennifer L. Boes, Stefanie Galba.ń, Alnawaz Rehemtulla, Timothy D. Johnson, Kenneth Pienta, Craig J. Galbán, Charles R. Meyer, Timothy Schakel, Klaas Nicolay, Ajjai S. Alva, Maha Hussain, Brian D. Ross

Research output: Contribution to journalArticle

Abstract

Bone metastasis occurs for men with advanced prostate cancer which promotes osseous growth and destruction driven by alterations in osteoblast and osteoclast homeostasis. Patients can experience pain, spontaneous fractures and morbidity eroding overall quality of life. The complex and dynamic cellular interactions within the bone microenvironment limit current treatment options thus prostate to bone metastases remains incurable. This study uses voxel-based analysis of diffusion-weighted MRI and CT scans to simultaneously evaluate temporal changes in normal bone homeostasis along with prostate bone metatastsis to deliver an improved understanding of the spatiotemporal local microenvironment. Dynamic tumor-stromal interactions were assessed during treatment in mouse models along with a pilot prospective clinical trial with metastatic hormone sensitive and castration resistant prostate cancer patients with bone metastases. Longitudinal changes in tumor and bone imaging metrics during delivery of therapy were quantified. Studies revealed that voxel-based parametric response maps (PRM) of DW-MRI and CT scans could be used to quantify and spatially visualize dynamic changes during prostate tumor growth and in response to treatment thereby distinguishing patients with stable disease from those with progressive disease (p

Original languageEnglish (US)
Article numbere123877
JournalPLoS One
Volume10
Issue number4
DOIs
StatePublished - Apr 10 2015
Externally publishedYes

Fingerprint

Multimodal Imaging
prostatic neoplasms
Tumors
Prostatic Neoplasms
Bone
bones
image analysis
Imaging techniques
Bone and Bones
neoplasms
Neoplasms
metastasis
Prostate
Computerized tomography
Neoplasm Metastasis
computed tomography
homeostasis
Homeostasis
Magnetic Resonance Imaging
Spontaneous Fractures

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Brisset, J. C., Hoff, B. A., Chenevert, T. L., Jacobson, J. A., Boes, J. L., Galba.ń, S., ... Ross, B. D. (2015). Integrated multimodal imaging of dynamic bone-tumor alterations associated with metastatic prostate cancer. PLoS One, 10(4), [e123877]. https://doi.org/10.1371/journal.pone.0123877

Integrated multimodal imaging of dynamic bone-tumor alterations associated with metastatic prostate cancer. / Brisset, Jean Christophe; Hoff, Benjamin A.; Chenevert, Thomas L.; Jacobson, Jon A.; Boes, Jennifer L.; Galba.ń, Stefanie; Rehemtulla, Alnawaz; Johnson, Timothy D.; Pienta, Kenneth; Galbán, Craig J.; Meyer, Charles R.; Schakel, Timothy; Nicolay, Klaas; Alva, Ajjai S.; Hussain, Maha; Ross, Brian D.

In: PLoS One, Vol. 10, No. 4, e123877, 10.04.2015.

Research output: Contribution to journalArticle

Brisset, JC, Hoff, BA, Chenevert, TL, Jacobson, JA, Boes, JL, Galba.ń, S, Rehemtulla, A, Johnson, TD, Pienta, K, Galbán, CJ, Meyer, CR, Schakel, T, Nicolay, K, Alva, AS, Hussain, M & Ross, BD 2015, 'Integrated multimodal imaging of dynamic bone-tumor alterations associated with metastatic prostate cancer', PLoS One, vol. 10, no. 4, e123877. https://doi.org/10.1371/journal.pone.0123877
Brisset JC, Hoff BA, Chenevert TL, Jacobson JA, Boes JL, Galba.ń S et al. Integrated multimodal imaging of dynamic bone-tumor alterations associated with metastatic prostate cancer. PLoS One. 2015 Apr 10;10(4). e123877. https://doi.org/10.1371/journal.pone.0123877
Brisset, Jean Christophe ; Hoff, Benjamin A. ; Chenevert, Thomas L. ; Jacobson, Jon A. ; Boes, Jennifer L. ; Galba.ń, Stefanie ; Rehemtulla, Alnawaz ; Johnson, Timothy D. ; Pienta, Kenneth ; Galbán, Craig J. ; Meyer, Charles R. ; Schakel, Timothy ; Nicolay, Klaas ; Alva, Ajjai S. ; Hussain, Maha ; Ross, Brian D. / Integrated multimodal imaging of dynamic bone-tumor alterations associated with metastatic prostate cancer. In: PLoS One. 2015 ; Vol. 10, No. 4.
@article{72a61aabbfd442f8899c4cd5a855c243,
title = "Integrated multimodal imaging of dynamic bone-tumor alterations associated with metastatic prostate cancer",
abstract = "Bone metastasis occurs for men with advanced prostate cancer which promotes osseous growth and destruction driven by alterations in osteoblast and osteoclast homeostasis. Patients can experience pain, spontaneous fractures and morbidity eroding overall quality of life. The complex and dynamic cellular interactions within the bone microenvironment limit current treatment options thus prostate to bone metastases remains incurable. This study uses voxel-based analysis of diffusion-weighted MRI and CT scans to simultaneously evaluate temporal changes in normal bone homeostasis along with prostate bone metatastsis to deliver an improved understanding of the spatiotemporal local microenvironment. Dynamic tumor-stromal interactions were assessed during treatment in mouse models along with a pilot prospective clinical trial with metastatic hormone sensitive and castration resistant prostate cancer patients with bone metastases. Longitudinal changes in tumor and bone imaging metrics during delivery of therapy were quantified. Studies revealed that voxel-based parametric response maps (PRM) of DW-MRI and CT scans could be used to quantify and spatially visualize dynamic changes during prostate tumor growth and in response to treatment thereby distinguishing patients with stable disease from those with progressive disease (p",
author = "Brisset, {Jean Christophe} and Hoff, {Benjamin A.} and Chenevert, {Thomas L.} and Jacobson, {Jon A.} and Boes, {Jennifer L.} and Stefanie Galba.ń and Alnawaz Rehemtulla and Johnson, {Timothy D.} and Kenneth Pienta and Galb{\'a}n, {Craig J.} and Meyer, {Charles R.} and Timothy Schakel and Klaas Nicolay and Alva, {Ajjai S.} and Maha Hussain and Ross, {Brian D.}",
year = "2015",
month = "4",
day = "10",
doi = "10.1371/journal.pone.0123877",
language = "English (US)",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

TY - JOUR

T1 - Integrated multimodal imaging of dynamic bone-tumor alterations associated with metastatic prostate cancer

AU - Brisset, Jean Christophe

AU - Hoff, Benjamin A.

AU - Chenevert, Thomas L.

AU - Jacobson, Jon A.

AU - Boes, Jennifer L.

AU - Galba.ń, Stefanie

AU - Rehemtulla, Alnawaz

AU - Johnson, Timothy D.

AU - Pienta, Kenneth

AU - Galbán, Craig J.

AU - Meyer, Charles R.

AU - Schakel, Timothy

AU - Nicolay, Klaas

AU - Alva, Ajjai S.

AU - Hussain, Maha

AU - Ross, Brian D.

PY - 2015/4/10

Y1 - 2015/4/10

N2 - Bone metastasis occurs for men with advanced prostate cancer which promotes osseous growth and destruction driven by alterations in osteoblast and osteoclast homeostasis. Patients can experience pain, spontaneous fractures and morbidity eroding overall quality of life. The complex and dynamic cellular interactions within the bone microenvironment limit current treatment options thus prostate to bone metastases remains incurable. This study uses voxel-based analysis of diffusion-weighted MRI and CT scans to simultaneously evaluate temporal changes in normal bone homeostasis along with prostate bone metatastsis to deliver an improved understanding of the spatiotemporal local microenvironment. Dynamic tumor-stromal interactions were assessed during treatment in mouse models along with a pilot prospective clinical trial with metastatic hormone sensitive and castration resistant prostate cancer patients with bone metastases. Longitudinal changes in tumor and bone imaging metrics during delivery of therapy were quantified. Studies revealed that voxel-based parametric response maps (PRM) of DW-MRI and CT scans could be used to quantify and spatially visualize dynamic changes during prostate tumor growth and in response to treatment thereby distinguishing patients with stable disease from those with progressive disease (p

AB - Bone metastasis occurs for men with advanced prostate cancer which promotes osseous growth and destruction driven by alterations in osteoblast and osteoclast homeostasis. Patients can experience pain, spontaneous fractures and morbidity eroding overall quality of life. The complex and dynamic cellular interactions within the bone microenvironment limit current treatment options thus prostate to bone metastases remains incurable. This study uses voxel-based analysis of diffusion-weighted MRI and CT scans to simultaneously evaluate temporal changes in normal bone homeostasis along with prostate bone metatastsis to deliver an improved understanding of the spatiotemporal local microenvironment. Dynamic tumor-stromal interactions were assessed during treatment in mouse models along with a pilot prospective clinical trial with metastatic hormone sensitive and castration resistant prostate cancer patients with bone metastases. Longitudinal changes in tumor and bone imaging metrics during delivery of therapy were quantified. Studies revealed that voxel-based parametric response maps (PRM) of DW-MRI and CT scans could be used to quantify and spatially visualize dynamic changes during prostate tumor growth and in response to treatment thereby distinguishing patients with stable disease from those with progressive disease (p

UR - http://www.scopus.com/inward/record.url?scp=84928881051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928881051&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0123877

DO - 10.1371/journal.pone.0123877

M3 - Article

C2 - 25859981

AN - SCOPUS:84928881051

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 4

M1 - e123877

ER -