Integrated multi-electrode fluidic nitric-oxide sensor and VLSI potentiostat array

M. Naware, A. Rege, R. Genov, M. Stanacevic, G. Cauwenberghs, N. Thakor

Research output: Contribution to journalConference articlepeer-review

Abstract

Nitric Oxide (NO) serves as an important intercellular messenger in the human body, and is mechanistically involved in vascular disease, stroke, chronic hear failure, and epilepsy. We present a multi-electrode NO measurement sensor with integrated microfluidics. An array of carbon-based electrodes detect the spatial and temporal diffusion profile of NO in a PDMS laminar fluidic channel. The array interfaces to a multichannel potentiostatic VLSI system recording the amperometric output in real time, with five orders of magnitude in dynamic range over four scales down to hundreds of picoamperes. The integrated sensor-fluidic-VLSI system is expected to serve as a powerful tool to study the diffusion mechanism of NO under different fluid flow paradigms.

Original languageEnglish (US)
Pages (from-to)IV-25-IV-28
JournalProceedings - IEEE International Symposium on Circuits and Systems
Volume4
StatePublished - Sep 6 2004
Event2004 IEEE International Symposium on Circuits and Systems - Proceedings - Vancouver, BC, Canada
Duration: May 23 2004May 26 2004

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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