Nitric Oxide (NO) serves as an important intercellular messenger in the human body, and is mechanistically involved in vascular disease, stroke, chronic hear failure, and epilepsy. We present a multi-electrode NO measurement sensor with integrated microfluidics. An array of carbon-based electrodes detect the spatial and temporal diffusion profile of NO in a PDMS laminar fluidic channel. The array interfaces to a multichannel potentiostatic VLSI system recording the amperometric output in real time, with five orders of magnitude in dynamic range over four scales down to hundreds of picoamperes. The integrated sensor-fluidic-VLSI system is expected to serve as a powerful tool to study the diffusion mechanism of NO under different fluid flow paradigms.
|Original language||English (US)|
|Journal||Proceedings - IEEE International Symposium on Circuits and Systems|
|State||Published - Sep 6 2004|
|Event||2004 IEEE International Symposium on Circuits and Systems - Proceedings - Vancouver, BC, Canada|
Duration: May 23 2004 → May 26 2004
ASJC Scopus subject areas
- Electrical and Electronic Engineering