Abstract
Nitric Oxide (NO) serves as an important intercellular messenger in the human body, and is mechanistically involved in vascular disease, stroke, chronic hear failure, and epilepsy. We present a multi-electrode NO measurement sensor with integrated microfluidics. An array of carbon-based electrodes detect the spatial and temporal diffusion profile of NO in a PDMS laminar fluidic channel. The array interfaces to a multichannel potentiostatic VLSI system recording the amperometric output in real time, with five orders of magnitude in dynamic range over four scales down to hundreds of picoamperes. The integrated sensor-fluidic-VLSI system is expected to serve as a powerful tool to study the diffusion mechanism of NO under different fluid flow paradigms.
Original language | English (US) |
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Pages (from-to) | IV-25-IV-28 |
Journal | Proceedings - IEEE International Symposium on Circuits and Systems |
Volume | 4 |
State | Published - 2004 |
Event | 2004 IEEE International Symposium on Circuits and Systems - Proceedings - Vancouver, BC, Canada Duration: May 23 2004 → May 26 2004 |
ASJC Scopus subject areas
- Electrical and Electronic Engineering