Integrated MRI assessment of regional function and perfusion in canine myocardial infarction

Dara L. Kraitchman, Alistair A. Young, Daniel C. Bloomgarden, Zahi A. Fayad, Lawrence Dougherty, Victor A. Ferrari, Raymond C. Boston, Leon Axel

Research output: Contribution to journalArticlepeer-review

Abstract

A single integrated examination using regional measurements of perfusion from contrast-enhanced MRI and three-dimensional (3D) strain from tissue- tagged MRI was developed to differentiate infarcted myocardium from adjacent tissue with functional abnormalities. Ten dogs were studied at baseline and 10 days after a 2-hour occlusion of the left anterior descending coronary artery (LAD). Strain was determined using a 3D finite element model. Two- dimensional measurements of hypoenhancing regions were highly correlated with myocardial viability (r = 0.96). Signal intensity versus time curves obtained from contrast-enhanced MRI were used for quantitative perfusion analysis. The remote and adjacent noninfarcted tissue of the dogs with LAD occlusion, as well as the infarcted tissue, exhibited abnormal deformation patterns as compared to normal dogs (positive predictive value (PPV) of strain determination of infarction = 66%). Integration of contrast-enhanced MRI results with 3D strain analysis enabled the delineation of the myocardial infarction (PPV = 100%) from functionally compromised myocardium. This integrated cardiac examination shows promise for noninvasive serial assessment of potentially jeopardized noninfarcted myocardium to study the process of infarct remodeling and expansion.

Original languageEnglish (US)
Pages (from-to)311-326
Number of pages16
JournalMagnetic resonance in medicine
Volume40
Issue number2
DOIs
StatePublished - Aug 1998

Keywords

  • Cardiac MRI
  • Left ventricular mechanics
  • Myocardial infarction
  • Myocardial perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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