Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes

Ian Ganly, Vladimir Makarov, Shyamprasad Deraje, Yi Yu Dong, Ed Reznik, Venkatraman Seshan, Gouri Nanjangud, Stephanie Eng, Promita Bose, Fengshen Kuo, Luc G.T. Morris, Inigo Landa, Pedro Blecua Carrillo Albornoz, Nadeem Riaz, Yuri E. Nikiforov, Kepal Patel, Christopher Umbricht, Martha A Zeiger, Electron Kebebew, Eric ShermanRonald Ghossein, James A. Fagin, Timothy A. Chan

Research output: Contribution to journalArticle

Abstract

The molecular foundations of Hürthle cell carcinoma (HCC) are poorly understood. Here we describe a comprehensive genomic characterization of 56 primary HCC tumors that span the spectrum of tumor behavior. We elucidate the mutational profile and driver mutations and show that these tumors exhibit a wide range of recurrent mutations. Notably, we report a high number of disruptive mutations to both protein-coding and tRNA-encoding regions of the mitochondrial genome. We reveal unique chromosomal landscapes that involve whole-chromosomal duplications of chromosomes 5 and 7 and widespread loss of heterozygosity arising from haploidization and copy-number-neutral uniparental disomy. We also identify fusion genes and disrupted signaling pathways that may drive disease pathogenesis. Ganly et al. elucidate recurrent mutations impacting the RTK/RAS/AKT/mTOR pathway, DNA damage/repair, epigenetic modifiers, TERT promoter, and the mitochondrial genome in Hürthle cell carcinoma (HCC). HCCs also display prevalent chromosome 5 and 7 duplications, loss of heterozygosity, and in-frame gene fusions.

Original languageEnglish (US)
JournalCancer Cell
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • copy-number alterations
  • fusion genes
  • genomics
  • Hurthle cell carcinoma
  • mitochondrial mutations
  • transcriptome

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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  • Cite this

    Ganly, I., Makarov, V., Deraje, S., Dong, Y. Y., Reznik, E., Seshan, V., Nanjangud, G., Eng, S., Bose, P., Kuo, F., Morris, L. G. T., Landa, I., Carrillo Albornoz, P. B., Riaz, N., Nikiforov, Y. E., Patel, K., Umbricht, C., Zeiger, M. A., Kebebew, E., ... Chan, T. A. (Accepted/In press). Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes. Cancer Cell. https://doi.org/10.1016/j.ccell.2018.07.002