TY - JOUR
T1 - Integrated concentrations of growth hormone, insulin, C-peptide and prolactin in human obesity
AU - Meistas, Mary T.
AU - Foster, Giraud V.
AU - Margolis, Simeon
AU - Kowarski, A. Avinoam
PY - 1982/12
Y1 - 1982/12
N2 - Twenty-four hour integrated concentrations of growth hormone (IC-GH) were significantly lower in young, obese subjects than in young subjects who were lean. Significant inverse correlations were found between IC-GH and body mass index (BMI) as well as the IC-GH and the 24 hr integrated concentrations of insulin (IC-I) and C-peptide (IC-C) in obese subjects below 30 yr of age. Since IC-GH decreases with age, the effect of obesity on IC-GH could not be demonstrated in the older subjects; a weak inverse correlation (p < 0.05) between IC-GH and IC-C was found. Prolactin was significantly lower in the older subjects but did not correlate with IC-GH and was similar in lean and obese. Lipid deposition in adipose cells is promoted by high concentrations of insulin as well as low concentrations of growth hormone. We found a significant correlation between the IC-I IC-GH ratio and BMI of both the young and older subjects. Correlations between these two factors do not necessarily imply a cause and effect relationship. It is plausible, however, that the elevated IC-I IC-GH of the obese may facilitate their lipid storage and counter their efforts at weight reduction.
AB - Twenty-four hour integrated concentrations of growth hormone (IC-GH) were significantly lower in young, obese subjects than in young subjects who were lean. Significant inverse correlations were found between IC-GH and body mass index (BMI) as well as the IC-GH and the 24 hr integrated concentrations of insulin (IC-I) and C-peptide (IC-C) in obese subjects below 30 yr of age. Since IC-GH decreases with age, the effect of obesity on IC-GH could not be demonstrated in the older subjects; a weak inverse correlation (p < 0.05) between IC-GH and IC-C was found. Prolactin was significantly lower in the older subjects but did not correlate with IC-GH and was similar in lean and obese. Lipid deposition in adipose cells is promoted by high concentrations of insulin as well as low concentrations of growth hormone. We found a significant correlation between the IC-I IC-GH ratio and BMI of both the young and older subjects. Correlations between these two factors do not necessarily imply a cause and effect relationship. It is plausible, however, that the elevated IC-I IC-GH of the obese may facilitate their lipid storage and counter their efforts at weight reduction.
UR - http://www.scopus.com/inward/record.url?scp=0020375156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020375156&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(82)90008-7
DO - 10.1016/0026-0495(82)90008-7
M3 - Article
C2 - 6755165
AN - SCOPUS:0020375156
VL - 31
SP - 1224
EP - 1228
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 12
ER -