TY - JOUR
T1 - Integrated concentrations of growth hormone, insulin, C-peptide and prolactin in human obesity
AU - Meistas, Mary T.
AU - Foster, Giraud V.
AU - Margolis, Simeon
AU - Kowarski, A. Avinoam
N1 - Funding Information:
From the Departments of Pediatrics, Medicine. Obstetrics and Gynecoiogy. The Johns Hopkins University School of Medicine, Baltimore MD, and the Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD. Received for publication June I7. 1982. Supported in part by Research Grants HD-36077 and Training Grant AM-07109 of the National Institutes of Health, United States Public Health Service. The patients were studied at the Johns Hopkins CIinicaf Research Center of Pediatrics which is supported by Gram RR-0052 from the General Chnical Research Centers Program of the Division of Research Resources. National Institutes of Health. Address reprint requesis to A. Avinoam Kowarski. M.D.. University of Maryland School of Medicine, Howard Hall Tower I O-047, Baltimore, MD 21201. 01982 by Grune & Stratton, Inc. 0026-0495/82/3112-0008$01.00/0
PY - 1982/12
Y1 - 1982/12
N2 - Twenty-four hour integrated concentrations of growth hormone (IC-GH) were significantly lower in young, obese subjects than in young subjects who were lean. Significant inverse correlations were found between IC-GH and body mass index (BMI) as well as the IC-GH and the 24 hr integrated concentrations of insulin (IC-I) and C-peptide (IC-C) in obese subjects below 30 yr of age. Since IC-GH decreases with age, the effect of obesity on IC-GH could not be demonstrated in the older subjects; a weak inverse correlation (p < 0.05) between IC-GH and IC-C was found. Prolactin was significantly lower in the older subjects but did not correlate with IC-GH and was similar in lean and obese. Lipid deposition in adipose cells is promoted by high concentrations of insulin as well as low concentrations of growth hormone. We found a significant correlation between the IC-I IC-GH ratio and BMI of both the young and older subjects. Correlations between these two factors do not necessarily imply a cause and effect relationship. It is plausible, however, that the elevated IC-I IC-GH of the obese may facilitate their lipid storage and counter their efforts at weight reduction.
AB - Twenty-four hour integrated concentrations of growth hormone (IC-GH) were significantly lower in young, obese subjects than in young subjects who were lean. Significant inverse correlations were found between IC-GH and body mass index (BMI) as well as the IC-GH and the 24 hr integrated concentrations of insulin (IC-I) and C-peptide (IC-C) in obese subjects below 30 yr of age. Since IC-GH decreases with age, the effect of obesity on IC-GH could not be demonstrated in the older subjects; a weak inverse correlation (p < 0.05) between IC-GH and IC-C was found. Prolactin was significantly lower in the older subjects but did not correlate with IC-GH and was similar in lean and obese. Lipid deposition in adipose cells is promoted by high concentrations of insulin as well as low concentrations of growth hormone. We found a significant correlation between the IC-I IC-GH ratio and BMI of both the young and older subjects. Correlations between these two factors do not necessarily imply a cause and effect relationship. It is plausible, however, that the elevated IC-I IC-GH of the obese may facilitate their lipid storage and counter their efforts at weight reduction.
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U2 - 10.1016/0026-0495(82)90008-7
DO - 10.1016/0026-0495(82)90008-7
M3 - Article
C2 - 6755165
AN - SCOPUS:0020375156
VL - 31
SP - 1224
EP - 1228
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 12
ER -