Abstract
The integrated concentration (I.C.) of plasma aldosterone ' and cortisol was determined every 30 min during a 24-h period, using a blood collection system composed of a nonthrombogenic catheter and a small, portable withdrawal pump. The experiments were carried out in 8 normal adult men during daily routine life, and repeated in 2 of the subjects while recumbent in bed most of the day. The following conclusions were made: a) The 30-min I.C. of aldosterone fluctuated widely throughout the day. b) Although peaks of increased concentration occurred after a change in posture from supine to erect, there were many peaks of concentration that occurred during the supine posture. The 24-h I.C. of aldosterone in 2 subjects that were studied a second time while staying in bed most of the day was lower than the I.C. observed during normal activity. Furthermore, there was a significant correlation between 24-h I.C. and percentage of time spent in supine position, c) A weak, but significant correlation was found between the 30-min I.C. of aldosterone and cortisol in 4 out of the 7 subjects tested. The overall correlation for all experiments was also significant (R = 0.3, P < 0.001). d) The 4-h I.C. of aldosterone and cortisol showed that the lowest mean values were between 4 PM and 4 AM and the highest values between 4 AM and 4 PM for both steroids.
Original language | English (US) |
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Pages (from-to) | 205-210 |
Number of pages | 6 |
Journal | Journal of Clinical Endocrinology and Metabolism |
Volume | 40 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1975 |
Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical