Integrated cluster- and case-based surveillance for detecting stage III zoonotic pathogens

An example of Nipah virus surveillance in Bangladesh

A. M. Naser, M. J. Hossain, H. M.S. Sazzad, N. Homaira, Emily Gurley, G. Podder, S. Afroj, S. Banu, P. E. Rollin, P. Daszak, B. N. Ahmed, M. Rahman, S. P. Luby

Research output: Contribution to journalArticle

Abstract

This paper explores the utility of cluster- and case-based surveillance established in government hospitals in Bangladesh to detect Nipah virus, a stage III zoonotic pathogen. Physicians listed meningo-encephalitis cases in the 10 surveillance hospitals and identified a cluster when ≥2 cases who lived within 30 min walking distance of one another developed symptoms within 3 weeks of each other. Physicians collected blood samples from the clustered cases. As part of case-based surveillance, blood was collected from all listed meningo-encephalitis cases in three hospitals during the Nipah season (January-March). An investigation team visited clustered cases' communities to collect epidemiological information and blood from the living cases. We tested serum using Nipah-specific IgM ELISA. Up to September 2011, in 5887 listed cases, we identified 62 clusters comprising 176 encephalitis cases. We collected blood from 127 of these cases. In 10 clusters, we identified a total of 62 Nipah cases: 18 laboratory-confirmed and 34 probable. We identified person-to-person transmission of Nipah virus in four clusters. From case-based surveillance, we identified 23 (4%) Nipah cases. Faced with thousands of encephalitis cases, integrated cluster surveillance allows targeted deployment of investigative resources to detect outbreaks by stage III zoonotic pathogens in resource-limited settings.

Original languageEnglish (US)
Pages (from-to)1922-1930
Number of pages9
JournalEpidemiology and Infection
Volume143
Issue number9
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Fingerprint

Nipah Virus
Bangladesh
Zoonoses
Encephalitis
Physicians
Walking
Disease Outbreaks
Immunoglobulin M
Enzyme-Linked Immunosorbent Assay
Serum

Keywords

  • Cluster
  • encephalitis
  • Nipah
  • outbreak
  • stage III pathogen
  • surveillance

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

Cite this

Integrated cluster- and case-based surveillance for detecting stage III zoonotic pathogens : An example of Nipah virus surveillance in Bangladesh. / Naser, A. M.; Hossain, M. J.; Sazzad, H. M.S.; Homaira, N.; Gurley, Emily; Podder, G.; Afroj, S.; Banu, S.; Rollin, P. E.; Daszak, P.; Ahmed, B. N.; Rahman, M.; Luby, S. P.

In: Epidemiology and Infection, Vol. 143, No. 9, 01.07.2015, p. 1922-1930.

Research output: Contribution to journalArticle

Naser, AM, Hossain, MJ, Sazzad, HMS, Homaira, N, Gurley, E, Podder, G, Afroj, S, Banu, S, Rollin, PE, Daszak, P, Ahmed, BN, Rahman, M & Luby, SP 2015, 'Integrated cluster- and case-based surveillance for detecting stage III zoonotic pathogens: An example of Nipah virus surveillance in Bangladesh', Epidemiology and Infection, vol. 143, no. 9, pp. 1922-1930. https://doi.org/10.1017/S0950268814002635
Naser, A. M. ; Hossain, M. J. ; Sazzad, H. M.S. ; Homaira, N. ; Gurley, Emily ; Podder, G. ; Afroj, S. ; Banu, S. ; Rollin, P. E. ; Daszak, P. ; Ahmed, B. N. ; Rahman, M. ; Luby, S. P. / Integrated cluster- and case-based surveillance for detecting stage III zoonotic pathogens : An example of Nipah virus surveillance in Bangladesh. In: Epidemiology and Infection. 2015 ; Vol. 143, No. 9. pp. 1922-1930.
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