Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency

Carla R P Oliveira, Roberto Salvatori, Jose A S Barreto-Filho, Ivina E S Rocha, Andrea Mari, Rossana M C Pereira, Viviane C. Campos, Menilsson Menezes, Elenilde Gomes, Rafael A. Meneguz-Moreno, Vanessa P. Araújo, Natália T F Leite, Adão C. Nascimento, Maria I T Farias, Thaisa A R Viscente, Raquel D C Araújo, Enaldo V. Melo, Manuel H. Aguiar-Oliveira

Research output: Contribution to journalArticle

Abstract

Context: GH reduces insulin sensitivity (IS), whereas IGF-I increases it. IGF-I seems to be critical for the development of the β-cells, and impaired IS has been reported in GH deficiency (GHD). Objective: The aim of the study was to assess IS and β-cell function in adult patients with untreated isolated GHD (IGHD) due to a homozygous mutation in the GHRH receptor gene. Design, Setting, and Patients: We conducted a cross-sectional study in 24 GH-naive adult IGHD subjects and 25 controls. Intervention:Weperformed an oral glucose tolerance test with glucose and insulin measurements at 0, 30, 60, 90, 120, and 180 min. Main Outcome Measures: IS was assessed by homeostasis model assessment index of insulin resistance (IR), quantitative IS check index, oral glucose IS in 2 h (OGIS2) and 3 h (OGIS3). β-Cell function was assayed by homeostasis model assessment index-β, insulinogenic index, and area under the curve of insulin-glucose ratio. Results: During theoral glucose tolerance test, glucose levels were higher in IGHD subjects (P

Original languageEnglish (US)
Pages (from-to)1013-1019
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number3
DOIs
StatePublished - Mar 2012

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Pituitary Dwarfism
Growth Hormone
Insulin Resistance
Insulin
Glucose
Glucose Tolerance Test
Insulin-Like Growth Factor I
Homeostasis
Area Under Curve
Cross-Sectional Studies
Outcome Assessment (Health Care)
Mutation
Genes

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Oliveira, C. R. P., Salvatori, R., Barreto-Filho, J. A. S., Rocha, I. E. S., Mari, A., Pereira, R. M. C., ... Aguiar-Oliveira, M. H. (2012). Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism, 97(3), 1013-1019. https://doi.org/10.1210/jc.2011-2590

Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency. / Oliveira, Carla R P; Salvatori, Roberto; Barreto-Filho, Jose A S; Rocha, Ivina E S; Mari, Andrea; Pereira, Rossana M C; Campos, Viviane C.; Menezes, Menilsson; Gomes, Elenilde; Meneguz-Moreno, Rafael A.; Araújo, Vanessa P.; Leite, Natália T F; Nascimento, Adão C.; Farias, Maria I T; Viscente, Thaisa A R; Araújo, Raquel D C; Melo, Enaldo V.; Aguiar-Oliveira, Manuel H.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 3, 03.2012, p. 1013-1019.

Research output: Contribution to journalArticle

Oliveira, CRP, Salvatori, R, Barreto-Filho, JAS, Rocha, IES, Mari, A, Pereira, RMC, Campos, VC, Menezes, M, Gomes, E, Meneguz-Moreno, RA, Araújo, VP, Leite, NTF, Nascimento, AC, Farias, MIT, Viscente, TAR, Araújo, RDC, Melo, EV & Aguiar-Oliveira, MH 2012, 'Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency', Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 3, pp. 1013-1019. https://doi.org/10.1210/jc.2011-2590
Oliveira, Carla R P ; Salvatori, Roberto ; Barreto-Filho, Jose A S ; Rocha, Ivina E S ; Mari, Andrea ; Pereira, Rossana M C ; Campos, Viviane C. ; Menezes, Menilsson ; Gomes, Elenilde ; Meneguz-Moreno, Rafael A. ; Araújo, Vanessa P. ; Leite, Natália T F ; Nascimento, Adão C. ; Farias, Maria I T ; Viscente, Thaisa A R ; Araújo, Raquel D C ; Melo, Enaldo V. ; Aguiar-Oliveira, Manuel H. / Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency. In: Journal of Clinical Endocrinology and Metabolism. 2012 ; Vol. 97, No. 3. pp. 1013-1019.
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