Abstract
Context: GH reduces insulin sensitivity (IS), whereas IGF-I increases it. IGF-I seems to be critical for the development of the β-cells, and impaired IS has been reported in GH deficiency (GHD). Objective: The aim of the study was to assess IS and β-cell function in adult patients with untreated isolated GHD (IGHD) due to a homozygous mutation in the GHRH receptor gene. Design, Setting, and Patients: We conducted a cross-sectional study in 24 GH-naive adult IGHD subjects and 25 controls. Intervention:Weperformed an oral glucose tolerance test with glucose and insulin measurements at 0, 30, 60, 90, 120, and 180 min. Main Outcome Measures: IS was assessed by homeostasis model assessment index of insulin resistance (IR), quantitative IS check index, oral glucose IS in 2 h (OGIS2) and 3 h (OGIS3). β-Cell function was assayed by homeostasis model assessment index-β, insulinogenic index, and area under the curve of insulin-glucose ratio. Results: During theoral glucose tolerance test, glucose levels were higher in IGHD subjects (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1013-1019 |
| Number of pages | 7 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 97 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2012 |
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ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Endocrinology
- Biochemistry, medical
- Endocrinology, Diabetes and Metabolism
Cite this
Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency. / Oliveira, Carla R P; Salvatori, Roberto; Barreto-Filho, Jose A S; Rocha, Ivina E S; Mari, Andrea; Pereira, Rossana M C; Campos, Viviane C.; Menezes, Menilsson; Gomes, Elenilde; Meneguz-Moreno, Rafael A.; Araújo, Vanessa P.; Leite, Natália T F; Nascimento, Adão C.; Farias, Maria I T; Viscente, Thaisa A R; Araújo, Raquel D C; Melo, Enaldo V.; Aguiar-Oliveira, Manuel H.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 3, 03.2012, p. 1013-1019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin sensitivity and β-cell function in adults with lifetime, untreated isolated growth hormone deficiency
AU - Oliveira, Carla R P
AU - Salvatori, Roberto
AU - Barreto-Filho, Jose A S
AU - Rocha, Ivina E S
AU - Mari, Andrea
AU - Pereira, Rossana M C
AU - Campos, Viviane C.
AU - Menezes, Menilsson
AU - Gomes, Elenilde
AU - Meneguz-Moreno, Rafael A.
AU - Araújo, Vanessa P.
AU - Leite, Natália T F
AU - Nascimento, Adão C.
AU - Farias, Maria I T
AU - Viscente, Thaisa A R
AU - Araújo, Raquel D C
AU - Melo, Enaldo V.
AU - Aguiar-Oliveira, Manuel H.
PY - 2012/3
Y1 - 2012/3
N2 - Context: GH reduces insulin sensitivity (IS), whereas IGF-I increases it. IGF-I seems to be critical for the development of the β-cells, and impaired IS has been reported in GH deficiency (GHD). Objective: The aim of the study was to assess IS and β-cell function in adult patients with untreated isolated GHD (IGHD) due to a homozygous mutation in the GHRH receptor gene. Design, Setting, and Patients: We conducted a cross-sectional study in 24 GH-naive adult IGHD subjects and 25 controls. Intervention:Weperformed an oral glucose tolerance test with glucose and insulin measurements at 0, 30, 60, 90, 120, and 180 min. Main Outcome Measures: IS was assessed by homeostasis model assessment index of insulin resistance (IR), quantitative IS check index, oral glucose IS in 2 h (OGIS2) and 3 h (OGIS3). β-Cell function was assayed by homeostasis model assessment index-β, insulinogenic index, and area under the curve of insulin-glucose ratio. Results: During theoral glucose tolerance test, glucose levels were higher in IGHD subjects (P
AB - Context: GH reduces insulin sensitivity (IS), whereas IGF-I increases it. IGF-I seems to be critical for the development of the β-cells, and impaired IS has been reported in GH deficiency (GHD). Objective: The aim of the study was to assess IS and β-cell function in adult patients with untreated isolated GHD (IGHD) due to a homozygous mutation in the GHRH receptor gene. Design, Setting, and Patients: We conducted a cross-sectional study in 24 GH-naive adult IGHD subjects and 25 controls. Intervention:Weperformed an oral glucose tolerance test with glucose and insulin measurements at 0, 30, 60, 90, 120, and 180 min. Main Outcome Measures: IS was assessed by homeostasis model assessment index of insulin resistance (IR), quantitative IS check index, oral glucose IS in 2 h (OGIS2) and 3 h (OGIS3). β-Cell function was assayed by homeostasis model assessment index-β, insulinogenic index, and area under the curve of insulin-glucose ratio. Results: During theoral glucose tolerance test, glucose levels were higher in IGHD subjects (P
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U2 - 10.1210/jc.2011-2590
DO - 10.1210/jc.2011-2590
M3 - Article
C2 - 22170707
AN - SCOPUS:84858031213
VL - 97
SP - 1013
EP - 1019
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 3
ER -