Insulin resistance and muscle strength in older persons

Angela M. Abbatecola, Luigi Ferrucci, GianPaolo Ceda, Cosimo R. Russo, Fulvio Lauretani, Stefania Bandinelli, Michelangela Barbieri, Giorgio Valenti, Giuseppe Paolisso

Research output: Contribution to journalArticlepeer-review

Abstract

Background. The functional consequences of an age-related insulin resistance (IR) state on muscle functioning are unknown. Because insulin is needed for adequate muscle function, an age-related insulin-resistant state may also be a determining factor. We evaluated the relationship between IR and handgrip muscle strength in men and women from a large population-based study (n = 968). Methods. The degree of IR was evaluated by the homeostasis model assessment (HOMA) and muscle strength was assessed using handgrip. Results. Simple sex-stratified correlations demonstrated that, in men. body mass index-adjusted handgrip strength correlated positively with physical activity (r = 0.321; p <.001), muscle area (r = 0.420; p <.001), muscle density (r = 0.263; p = .001), plasma albumin (r = 0.156; p = .001), insulin-like growth factor-1 (r = 0.258; p <.001), calcium (r = 0.140; p = .006), and testosterone (r = 0.325; p <.001) concentrations, whereas a negative association was found for age (r = -0.659; p <.001) and myoglobin plasma levels (r = -0.164; p = .001). In women, body mass index-adjusted handgrip strength correlated positively with physical activity (r = 0.280; p <.001), muscle area (r = 0.306; p <.001), muscle density (r = 0.341; p = .001), plasma albumin (r = 0.140; p = .001), and insulin-like growth factor-1 (r = 0.300; p <.001), whereas a negative association was found for age (r = -0.563; p <.001), myoglobin levels (r = -0.164; p = .001), and IR (r = -0.130; p = .04). Conclusions. Sex-stratified analyses adjusted for multiple confounders showed that the relationship between IR and handgrip strength was found significant in women, whereas it was negligible and not significant in men.

Original languageEnglish (US)
Pages (from-to)1278-1282
Number of pages5
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume60
Issue number10
StatePublished - Oct 2005
Externally publishedYes

ASJC Scopus subject areas

  • Aging

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