Insulin-like growth factors and cytokines in pediatric cancer

Lee J. Helman, Leonard H. Wexler

Research output: Contribution to journalReview articlepeer-review


The development of clinical applications for hematopoietic growth factors, differentiation and anti-proliferative factors, and immunoregulatory cytokines is still in its formative stages in the area of pediatric oncology. The relative rarity of pediatric cancers makes it difficult for large-scale studies of these new agents to be conducted. However, smaller pilot studies have been performed and offer clues as to their eventual clinical utility. This chapter will focus on those agents that have been most extensively evaluated in children with cancer and will discuss recent laboratory insights into basic mechanisms of tumorigensis that offer intriguing new strategies for clinical investigation.

Original languageEnglish (US)
Pages (from-to)331-354
Number of pages24
JournalGrowth Factors and Cytokines in Health and Disease
Issue numberC
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Cancer Research


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