Insulin-like growth factor type 1 (IGF-1) and igf binding protein-3 in patients with ewing sarcoma family of tumors

Jeffrey A. Toretsky, Seth M. Steinberg, Manjusha Thakar, Debra Counts, Baiba Pironis, Carrie Parente, Allen Eskenazi, Lee Helman, Leonard H. Wexler

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND. Ewing sarcoma family of tumors (ESFTs) are the second most common bone tumor, that most often affects persons ages 3-40 years. The ESFTs rely on signaling through the insulin-like growth factor-1 receptor (IGF-1R) for growth and transformation. The current studies were performed to determine the levels of IGF-1 and IGF binding protein-3 (IGFBP-3) in patients with ESFT. The authors then performed an exploratory analysis to evaluate whether IGF parameters could differentiate event free or overall survival in ESFT patients. METHODS, The authors measured serum levels of IGF-1 and IGFBP-3 by using a radioimmunoassay from 111 patients with ESFT with a median follow-up of 13 years from diagnosis. RESULTS. The IGF-1 levels were lower among patients with metastatic disease to the bones or the bone marrow compared with patients without metastasis to these sites (p2 = 0.021 and 0.0038, respectively). IGFBP-3 is known to sequester IGF-1; the ratios of IGFBP-3 to IGF-1 were evaluated. Patients with metastatic disease to any site had higher IGFBP-3 to IGF-1 ratios than patients with localized disease (p2 = 0.0067). There was a trend toward increased survival in patients with localized disease who had high IGFBP-3 to IGF-1 levels. Metastatic patients showed a similar trend. CONCLUSIONS. Levels of IGF-1 and IGFBP-3 in ESFT patients can identify patients with the most widespread disease. The IGFBP-3 to IGF-1 ratio in patients with either localized or metastatic disease identified patients with a trend toward increased survival. Further prospective evaluation with higher patient numbers might show a prognostic role for the IGFBP-3 to IGF-1 ratio in patients with ESFT.

Original languageEnglish (US)
Pages (from-to)2941-2947
Number of pages7
JournalCancer
Volume92
Issue number11
DOIs
StatePublished - Dec 1 2001

Keywords

  • Ewing sarcoma family of tumors
  • IGFBP-3
  • Insulin-like growth factor-1 (IGF-1)
  • Predictive markers

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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