Insulin-like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)

Konstantinos K. Tsilidis, Ruth C. Travis, Paul N. Appleby, Naomi E. Allen, Sara Lindström, Demetrius Albanes, Regina G. Ziegler, Marjorie L. McCullough, Afshan Siddiq, Aurelio Barricarte, Sonja I. Berndt, H. Bas Bueno-De-Mesquita, Stephen J. Chanock, E. David Crawford, W. Ryan Diver, Susan M. Gapstur, Edward Giovannucci, Fangyi Gu, Christopher A. Haiman, Richard B. Hayes & 15 others David J. Hunter, Mattias Johansson, Rudolf Kaaks, Laurence N. Kolonel, Peter Kraft, Loic Le Marchand, Kim Overvad, Silvia Polidoro, Elio Riboli, Fredrick R. Schumacher, Victoria L. Stevens, Dimitrios Trichopoulos, Jarmo Virtamo, Walter C. Willett, Timothy J. Key

Research output: Contribution to journalArticle

Abstract

It has been hypothesized that a high intake of dairy protein may increase prostate cancer risk by increasing the production of insulin-like growth factor 1 (IGF-1). Several single nucleotide polymorphisms (SNPs) have been weakly associated with circulating concentrations of IGF-1 and IGF binding protein 3 (IGFBP-3), but none of these SNPs was associated with risk of prostate cancer. We examined whether an association between 16 SNPs associated with circulating IGF-1 or IGFBP-3 concentrations and prostate cancer exists within subgroups defined by dietary protein intake in 5,253 cases and 4,963 controls of European ancestry within the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). The BPC3 includes nested case-control studies within large North-American and European cohorts. Per-allele odds ratios for prostate cancer for the SNPs were compared across tertiles of protein intake, which was expressed as the percentage of energy derived from total, animal, dairy or plant protein sources, using conditional logistic regression models. Total, animal, dairy and plant protein intakes were significantly positively associated with blood IGF-1 (p <0.01), but not with IGFBP-3 concentrations (p > 0.10) or with risk of prostate cancer (p > 0.20). After adjusting for multiple testing, the SNP-prostate cancer associations did not differ by intakes of protein, although two interactions by intake of plant protein were of marginal statistical significance [SSTR5 (somatostatin receptor 5)-rs197056 (uncorrected p for interaction, 0.001); SSTR5-rs197057 (uncorrected p for interaction, 0.002)]. We found no strong evidence that the associations between 16 IGF pathway SNPs and prostate cancer differed by intakes of dietary protein.

Original languageEnglish (US)
Pages (from-to)495-504
Number of pages10
JournalInternational Journal of Cancer
Volume133
Issue number2
DOIs
StatePublished - Jul 15 2013
Externally publishedYes

Fingerprint

Dietary Proteins
Somatomedins
Prostatic Neoplasms
Breast Neoplasms
Single Nucleotide Polymorphism
Insulin-Like Growth Factor Binding Protein 3
Plant Proteins
Genes
Logistic Models
Proteins
Case-Control Studies
Alleles
Odds Ratio

Keywords

  • diet
  • environment interaction
  • gene
  • genetic epidemiology
  • insulin-like growth factor
  • prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Insulin-like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). / Tsilidis, Konstantinos K.; Travis, Ruth C.; Appleby, Paul N.; Allen, Naomi E.; Lindström, Sara; Albanes, Demetrius; Ziegler, Regina G.; McCullough, Marjorie L.; Siddiq, Afshan; Barricarte, Aurelio; Berndt, Sonja I.; Bueno-De-Mesquita, H. Bas; Chanock, Stephen J.; Crawford, E. David; Diver, W. Ryan; Gapstur, Susan M.; Giovannucci, Edward; Gu, Fangyi; Haiman, Christopher A.; Hayes, Richard B.; Hunter, David J.; Johansson, Mattias; Kaaks, Rudolf; Kolonel, Laurence N.; Kraft, Peter; Le Marchand, Loic; Overvad, Kim; Polidoro, Silvia; Riboli, Elio; Schumacher, Fredrick R.; Stevens, Victoria L.; Trichopoulos, Dimitrios; Virtamo, Jarmo; Willett, Walter C.; Key, Timothy J.

In: International Journal of Cancer, Vol. 133, No. 2, 15.07.2013, p. 495-504.

Research output: Contribution to journalArticle

Tsilidis, KK, Travis, RC, Appleby, PN, Allen, NE, Lindström, S, Albanes, D, Ziegler, RG, McCullough, ML, Siddiq, A, Barricarte, A, Berndt, SI, Bueno-De-Mesquita, HB, Chanock, SJ, Crawford, ED, Diver, WR, Gapstur, SM, Giovannucci, E, Gu, F, Haiman, CA, Hayes, RB, Hunter, DJ, Johansson, M, Kaaks, R, Kolonel, LN, Kraft, P, Le Marchand, L, Overvad, K, Polidoro, S, Riboli, E, Schumacher, FR, Stevens, VL, Trichopoulos, D, Virtamo, J, Willett, WC & Key, TJ 2013, 'Insulin-like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)', International Journal of Cancer, vol. 133, no. 2, pp. 495-504. https://doi.org/10.1002/ijc.28042
Tsilidis, Konstantinos K. ; Travis, Ruth C. ; Appleby, Paul N. ; Allen, Naomi E. ; Lindström, Sara ; Albanes, Demetrius ; Ziegler, Regina G. ; McCullough, Marjorie L. ; Siddiq, Afshan ; Barricarte, Aurelio ; Berndt, Sonja I. ; Bueno-De-Mesquita, H. Bas ; Chanock, Stephen J. ; Crawford, E. David ; Diver, W. Ryan ; Gapstur, Susan M. ; Giovannucci, Edward ; Gu, Fangyi ; Haiman, Christopher A. ; Hayes, Richard B. ; Hunter, David J. ; Johansson, Mattias ; Kaaks, Rudolf ; Kolonel, Laurence N. ; Kraft, Peter ; Le Marchand, Loic ; Overvad, Kim ; Polidoro, Silvia ; Riboli, Elio ; Schumacher, Fredrick R. ; Stevens, Victoria L. ; Trichopoulos, Dimitrios ; Virtamo, Jarmo ; Willett, Walter C. ; Key, Timothy J. / Insulin-like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). In: International Journal of Cancer. 2013 ; Vol. 133, No. 2. pp. 495-504.
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abstract = "It has been hypothesized that a high intake of dairy protein may increase prostate cancer risk by increasing the production of insulin-like growth factor 1 (IGF-1). Several single nucleotide polymorphisms (SNPs) have been weakly associated with circulating concentrations of IGF-1 and IGF binding protein 3 (IGFBP-3), but none of these SNPs was associated with risk of prostate cancer. We examined whether an association between 16 SNPs associated with circulating IGF-1 or IGFBP-3 concentrations and prostate cancer exists within subgroups defined by dietary protein intake in 5,253 cases and 4,963 controls of European ancestry within the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). The BPC3 includes nested case-control studies within large North-American and European cohorts. Per-allele odds ratios for prostate cancer for the SNPs were compared across tertiles of protein intake, which was expressed as the percentage of energy derived from total, animal, dairy or plant protein sources, using conditional logistic regression models. Total, animal, dairy and plant protein intakes were significantly positively associated with blood IGF-1 (p <0.01), but not with IGFBP-3 concentrations (p > 0.10) or with risk of prostate cancer (p > 0.20). After adjusting for multiple testing, the SNP-prostate cancer associations did not differ by intakes of protein, although two interactions by intake of plant protein were of marginal statistical significance [SSTR5 (somatostatin receptor 5)-rs197056 (uncorrected p for interaction, 0.001); SSTR5-rs197057 (uncorrected p for interaction, 0.002)]. We found no strong evidence that the associations between 16 IGF pathway SNPs and prostate cancer differed by intakes of dietary protein.",
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AU - Appleby, Paul N.

AU - Allen, Naomi E.

AU - Lindström, Sara

AU - Albanes, Demetrius

AU - Ziegler, Regina G.

AU - McCullough, Marjorie L.

AU - Siddiq, Afshan

AU - Barricarte, Aurelio

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AU - Bueno-De-Mesquita, H. Bas

AU - Chanock, Stephen J.

AU - Crawford, E. David

AU - Diver, W. Ryan

AU - Gapstur, Susan M.

AU - Giovannucci, Edward

AU - Gu, Fangyi

AU - Haiman, Christopher A.

AU - Hayes, Richard B.

AU - Hunter, David J.

AU - Johansson, Mattias

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AU - Kolonel, Laurence N.

AU - Kraft, Peter

AU - Le Marchand, Loic

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AU - Stevens, Victoria L.

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AU - Virtamo, Jarmo

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AU - Key, Timothy J.

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