Insulin-like growth factor-1 receptor overexpression is associated with outcome in invasive urothelial carcinoma of urinary bladder: A retrospective study of patients treated using radical cystectomy

Nilda Gonzalez-Roibon, Jenny J. Kim, Sheila F. Faraj, Alcides Chaux, Stephania M. Bezerra, Enrico Munari, Carla Ellis, Rajni Sharma, Daniel Keizman, Trinity Bivalacqua, Mark Schoenberg, Mario Eisenberger, Michael A Carducci, George J. Netto

Research output: Contribution to journalArticle

Abstract

Objective To assess the insulin-like growth factor-1 receptor (IGF1R) expression in urothelial carcinoma (UC) and its prognostic role in relation to clinicopathologic parameters. Methods A total of 100 cases of invasive UC were evaluated using tissue microarrays. Membranous IGF1R staining was evaluated using immunohistochemistry. A scoring method analogous to that of HER2 expression in breast carcinoma was used, and the highest score was assigned in each tumor. IGF1R was considered overexpressed in cases with score ≥1. Results We found IGF1R overexpression in 62% of invasive UC. IGF1R overexpression was associated with race (P =.04) and pT category (P =.03). Median follow-up was 29 months (range, 0.5-212). Progression rate was 60%, and overall mortality and cancer-specific mortality rates were 69% and 51%, respectively. In invasive UC, IGF1R overexpression was significantly associated with overall mortality and cancer-specific mortality (Mantel Cox P =.0002 and P =.006, respectively). IGF1R overexpression was associated with increased hazard ratios (HRs) for overall mortality (HR = 2.63, P =.001) and cancer-specific mortality (HR = 2.45, P =.01), independently and after adjusting for clinicopathologic features and treatment modalities. Conclusion We found IGF1R overexpression in 62% of bladder UC. More importantly, IGF1R overexpression was a significant predictor of overall mortality and cancer-specific mortality, suggesting its potential role as a prognosticator in UC of bladder.

Original languageEnglish (US)
JournalUrology
Volume83
Issue number6
DOIs
StatePublished - 2014

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Somatomedin Receptors
Cystectomy
Urinary Bladder
Retrospective Studies
Carcinoma
Mortality
Neoplasms
Research Design
Immunohistochemistry
Staining and Labeling
Breast Neoplasms

ASJC Scopus subject areas

  • Urology

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Insulin-like growth factor-1 receptor overexpression is associated with outcome in invasive urothelial carcinoma of urinary bladder : A retrospective study of patients treated using radical cystectomy. / Gonzalez-Roibon, Nilda; Kim, Jenny J.; Faraj, Sheila F.; Chaux, Alcides; Bezerra, Stephania M.; Munari, Enrico; Ellis, Carla; Sharma, Rajni; Keizman, Daniel; Bivalacqua, Trinity; Schoenberg, Mark; Eisenberger, Mario; Carducci, Michael A; Netto, George J.

In: Urology, Vol. 83, No. 6, 2014.

Research output: Contribution to journalArticle

Gonzalez-Roibon, Nilda ; Kim, Jenny J. ; Faraj, Sheila F. ; Chaux, Alcides ; Bezerra, Stephania M. ; Munari, Enrico ; Ellis, Carla ; Sharma, Rajni ; Keizman, Daniel ; Bivalacqua, Trinity ; Schoenberg, Mark ; Eisenberger, Mario ; Carducci, Michael A ; Netto, George J. / Insulin-like growth factor-1 receptor overexpression is associated with outcome in invasive urothelial carcinoma of urinary bladder : A retrospective study of patients treated using radical cystectomy. In: Urology. 2014 ; Vol. 83, No. 6.
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abstract = "Objective To assess the insulin-like growth factor-1 receptor (IGF1R) expression in urothelial carcinoma (UC) and its prognostic role in relation to clinicopathologic parameters. Methods A total of 100 cases of invasive UC were evaluated using tissue microarrays. Membranous IGF1R staining was evaluated using immunohistochemistry. A scoring method analogous to that of HER2 expression in breast carcinoma was used, and the highest score was assigned in each tumor. IGF1R was considered overexpressed in cases with score ≥1. Results We found IGF1R overexpression in 62{\%} of invasive UC. IGF1R overexpression was associated with race (P =.04) and pT category (P =.03). Median follow-up was 29 months (range, 0.5-212). Progression rate was 60{\%}, and overall mortality and cancer-specific mortality rates were 69{\%} and 51{\%}, respectively. In invasive UC, IGF1R overexpression was significantly associated with overall mortality and cancer-specific mortality (Mantel Cox P =.0002 and P =.006, respectively). IGF1R overexpression was associated with increased hazard ratios (HRs) for overall mortality (HR = 2.63, P =.001) and cancer-specific mortality (HR = 2.45, P =.01), independently and after adjusting for clinicopathologic features and treatment modalities. Conclusion We found IGF1R overexpression in 62{\%} of bladder UC. More importantly, IGF1R overexpression was a significant predictor of overall mortality and cancer-specific mortality, suggesting its potential role as a prognosticator in UC of bladder.",
author = "Nilda Gonzalez-Roibon and Kim, {Jenny J.} and Faraj, {Sheila F.} and Alcides Chaux and Bezerra, {Stephania M.} and Enrico Munari and Carla Ellis and Rajni Sharma and Daniel Keizman and Trinity Bivalacqua and Mark Schoenberg and Mario Eisenberger and Carducci, {Michael A} and Netto, {George J.}",
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T1 - Insulin-like growth factor-1 receptor overexpression is associated with outcome in invasive urothelial carcinoma of urinary bladder

T2 - A retrospective study of patients treated using radical cystectomy

AU - Gonzalez-Roibon, Nilda

AU - Kim, Jenny J.

AU - Faraj, Sheila F.

AU - Chaux, Alcides

AU - Bezerra, Stephania M.

AU - Munari, Enrico

AU - Ellis, Carla

AU - Sharma, Rajni

AU - Keizman, Daniel

AU - Bivalacqua, Trinity

AU - Schoenberg, Mark

AU - Eisenberger, Mario

AU - Carducci, Michael A

AU - Netto, George J.

PY - 2014

Y1 - 2014

N2 - Objective To assess the insulin-like growth factor-1 receptor (IGF1R) expression in urothelial carcinoma (UC) and its prognostic role in relation to clinicopathologic parameters. Methods A total of 100 cases of invasive UC were evaluated using tissue microarrays. Membranous IGF1R staining was evaluated using immunohistochemistry. A scoring method analogous to that of HER2 expression in breast carcinoma was used, and the highest score was assigned in each tumor. IGF1R was considered overexpressed in cases with score ≥1. Results We found IGF1R overexpression in 62% of invasive UC. IGF1R overexpression was associated with race (P =.04) and pT category (P =.03). Median follow-up was 29 months (range, 0.5-212). Progression rate was 60%, and overall mortality and cancer-specific mortality rates were 69% and 51%, respectively. In invasive UC, IGF1R overexpression was significantly associated with overall mortality and cancer-specific mortality (Mantel Cox P =.0002 and P =.006, respectively). IGF1R overexpression was associated with increased hazard ratios (HRs) for overall mortality (HR = 2.63, P =.001) and cancer-specific mortality (HR = 2.45, P =.01), independently and after adjusting for clinicopathologic features and treatment modalities. Conclusion We found IGF1R overexpression in 62% of bladder UC. More importantly, IGF1R overexpression was a significant predictor of overall mortality and cancer-specific mortality, suggesting its potential role as a prognosticator in UC of bladder.

AB - Objective To assess the insulin-like growth factor-1 receptor (IGF1R) expression in urothelial carcinoma (UC) and its prognostic role in relation to clinicopathologic parameters. Methods A total of 100 cases of invasive UC were evaluated using tissue microarrays. Membranous IGF1R staining was evaluated using immunohistochemistry. A scoring method analogous to that of HER2 expression in breast carcinoma was used, and the highest score was assigned in each tumor. IGF1R was considered overexpressed in cases with score ≥1. Results We found IGF1R overexpression in 62% of invasive UC. IGF1R overexpression was associated with race (P =.04) and pT category (P =.03). Median follow-up was 29 months (range, 0.5-212). Progression rate was 60%, and overall mortality and cancer-specific mortality rates were 69% and 51%, respectively. In invasive UC, IGF1R overexpression was significantly associated with overall mortality and cancer-specific mortality (Mantel Cox P =.0002 and P =.006, respectively). IGF1R overexpression was associated with increased hazard ratios (HRs) for overall mortality (HR = 2.63, P =.001) and cancer-specific mortality (HR = 2.45, P =.01), independently and after adjusting for clinicopathologic features and treatment modalities. Conclusion We found IGF1R overexpression in 62% of bladder UC. More importantly, IGF1R overexpression was a significant predictor of overall mortality and cancer-specific mortality, suggesting its potential role as a prognosticator in UC of bladder.

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