Insulin-Like Growth Factor-1: A Promising Therapeutic Target for Peripheral Nerve Injury

Benjamin R. Slavin, Karim A. Sarhane, Nicholas von Guionneau, Phillip J. Hanwright, Chenhu Qiu, Hai Quan Mao, Ahmet Höke, Sami H. Tuffaha

Research output: Contribution to journalReview articlepeer-review

Abstract

Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative process. Insulin-like growth factor-1 (IGF-1) represents a promising therapeutic target to meet this need, given its well-described trophic and anti-apoptotic effects on neurons, Schwann cells (SCs), and myocytes. Here, we review the literature regarding the therapeutic potential of IGF-1 in PNI. We appraised the literature for the various approaches of IGF-1 administration with the aim of identifying which are the most promising in offering a pathway toward clinical application. We also sought to determine the optimal reported dosage ranges for the various delivery approaches that have been investigated.

Original languageEnglish (US)
Article number695850
JournalFrontiers in Bioengineering and Biotechnology
Volume9
DOIs
StatePublished - Jun 24 2021

Keywords

  • IGF-1
  • nanoparticle carrier
  • nerve regeneration
  • peripheral nerve injury
  • PNI
  • somatomedin C

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Histology
  • Biomedical Engineering

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