Insulin levels control female germline stem cell maintenance via the niche in Drosophila

Research output: Contribution to journalArticle

Abstract

Stem cell maintenance depends on local signals provided by specialized microenvironments, or niches, in which they reside. The potential role of systemic factors in stem cell maintenance, however, has remained largely unexplored. Here, we show that insulin signaling integrates the effects of diet and age on germline stem cell (GSC) maintenance through the dual regulation of cap cell number (via Notch signaling) and cap cell-GSC interaction (via E-cadherin) and that the normal process of GSC and niche cell loss that occurs with age can be suppressed by increased levels of insulin-like peptides. These results underscore the importance of systemic factors for the regulation of stem cell niches and, thereby, of stem cell numbers.

Original languageEnglish (US)
Pages (from-to)1117-1121
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue number4
DOIs
StatePublished - Jan 27 2009
Externally publishedYes

Fingerprint

Drosophila
Stem Cells
Maintenance
Insulin
Stem Cell Niche
Cell Count
Stem Cell Factor
Cadherins
Cell Communication
Diet
Peptides
Oogonial Stem Cells

Keywords

  • Aging
  • Diet
  • E-cadherin
  • Notch
  • Oogenesis

ASJC Scopus subject areas

  • General

Cite this

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