Instrumentation development of a SPECT-CT system to image awake mice

A. G. Weisenberger, B. Kross, S. Majewski, V. Popov, M. F. Smith, V. H. Tran, B. Welch, J. Baba, J. Goddard, M. Pomper, B. Tsui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report on the instrumentation development of a SPECT-CT system being configured at Johns Hopkins University to image the biodistribution of radiopharmaceuticals in unrestrained, unanesthetized mice. The gantry is a custom built x-ray computed tomography system based on the Siemens MicroCAT II imaging system. The x-ray system is composed of an 80 kVp (max), 4OW x-ray source and a 2048 × 3096-pixel detector (5-frames per second readout). The mouse will be anesthetized during the x-ray CT scan. SPECT imaging will be achieved using two low profile gamma cameras, 10 cm × 20 cm in size based on a 2×4 array of Hamamatsu H8500 (8×8 anode pads) flat panel position sensitive photomultiplier tubes (PSPMT). A NaI(Tl) scintillator array with 1.2 mm pitch is mounted to the PSPMT array. The front end readout electronics combine the anode outputs of the PSPMTs of the detector head. The data acquisition system is based on two CAEN 32 channel VME peak sensing analog-digital converter (ADC) modules per detector head to digitize the outputs. An infrared based animal position tracking system will be used to monitor the mouse's head position during a SPECT scan via infrared illuminated markers attached to the mouse's head. The mouse is confined in an infrared transparent burrow at the center of rotation of the gantry. The tracking system is able to track with sub-millimeter accuracy the mouse's head position at 10-15 frames per second.

Original languageEnglish (US)
Title of host publication2006 IEEE Nuclear Science Symposium - Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3000-3003
Number of pages4
ISBN (Print)1424405610, 9781424405619
DOIs
StatePublished - Jan 1 2006
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: Oct 29 2006Nov 4 2006

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume5
ISSN (Print)1095-7863

Other

Other2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
CountryUnited States
CitySan Diego, CA
Period10/29/0611/4/06

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Weisenberger, A. G., Kross, B., Majewski, S., Popov, V., Smith, M. F., Tran, V. H., Welch, B., Baba, J., Goddard, J., Pomper, M., & Tsui, B. (2006). Instrumentation development of a SPECT-CT system to image awake mice. In 2006 IEEE Nuclear Science Symposium - Conference Record (pp. 3000-3003). [4179663] (IEEE Nuclear Science Symposium Conference Record; Vol. 5). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2006.356506