Instrumentation development of a SPECT-CT system to image awake mice

A. G. Weisenberger; B. Kross; S. Majewski; V. Popov; M. F. Smith; V. H. Tran; B. Welch; J. Baba; J. Goddard; M. Pomper; B. Tsui

doi:10.1109/NSSMIC.2006.356506

Instrumentation development of a SPECT-CT system to image awake mice

A. G. Weisenberger, B. Kross, S. Majewski, V. Popov, M. F. Smith, V. H. Tran, B. Welch, J. Baba, J. Goddard, M. Pomper, B. Tsui

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

14 Scopus citations

Abstract

We report on the instrumentation development of a SPECT-CT system being configured at Johns Hopkins University to image the biodistribution of radiopharmaceuticals in unrestrained, unanesthetized mice. The gantry is a custom built x-ray computed tomography system based on the Siemens MicroCAT II imaging system. The x-ray system is composed of an 80 kVp (max), 4OW x-ray source and a 2048 × 3096-pixel detector (5-frames per second readout). The mouse will be anesthetized during the x-ray CT scan. SPECT imaging will be achieved using two low profile gamma cameras, 10 cm × 20 cm in size based on a 2×4 array of Hamamatsu H8500 (8×8 anode pads) flat panel position sensitive photomultiplier tubes (PSPMT). A NaI(Tl) scintillator array with 1.2 mm pitch is mounted to the PSPMT array. The front end readout electronics combine the anode outputs of the PSPMTs of the detector head. The data acquisition system is based on two CAEN 32 channel VME peak sensing analog-digital converter (ADC) modules per detector head to digitize the outputs. An infrared based animal position tracking system will be used to monitor the mouse's head position during a SPECT scan via infrared illuminated markers attached to the mouse's head. The mouse is confined in an infrared transparent burrow at the center of rotation of the gantry. The tracking system is able to track with sub-millimeter accuracy the mouse's head position at 10-15 frames per second.

Original language	English (US)
Title of host publication	2006 IEEE Nuclear Science Symposium - Conference Record
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	3000-3003
Number of pages	4
ISBN (Print)	1424405610, 9781424405619
DOIs	https://doi.org/10.1109/NSSMIC.2006.356506
State	Published - 2006
Event	2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States Duration: Oct 29 2006 → Nov 4 2006

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
Volume	5
ISSN (Print)	1095-7863

Other

Other	2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
Country/Territory	United States
City	San Diego, CA
Period	10/29/06 → 11/4/06

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

Access to Document

10.1109/NSSMIC.2006.356506

Cite this

Weisenberger, A. G., Kross, B., Majewski, S., Popov, V., Smith, M. F., Tran, V. H., Welch, B., Baba, J., Goddard, J., Pomper, M., & Tsui, B. (2006). Instrumentation development of a SPECT-CT system to image awake mice. In 2006 IEEE Nuclear Science Symposium - Conference Record (pp. 3000-3003). Article 4179663 (IEEE Nuclear Science Symposium Conference Record; Vol. 5). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2006.356506

Instrumentation development of a SPECT-CT system to image awake mice. / Weisenberger, A. G.; Kross, B.; Majewski, S. et al.
2006 IEEE Nuclear Science Symposium - Conference Record. Institute of Electrical and Electronics Engineers Inc., 2006. p. 3000-3003 4179663 (IEEE Nuclear Science Symposium Conference Record; Vol. 5).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Weisenberger, AG, Kross, B, Majewski, S, Popov, V, Smith, MF, Tran, VH, Welch, B, Baba, J, Goddard, J, Pomper, M & Tsui, B 2006, Instrumentation development of a SPECT-CT system to image awake mice. in 2006 IEEE Nuclear Science Symposium - Conference Record., 4179663, IEEE Nuclear Science Symposium Conference Record, vol. 5, Institute of Electrical and Electronics Engineers Inc., pp. 3000-3003, 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD, San Diego, CA, United States, 10/29/06. https://doi.org/10.1109/NSSMIC.2006.356506

@inproceedings{110f34aed06d494fa6bc59948cc51bfc,

title = "Instrumentation development of a SPECT-CT system to image awake mice",

abstract = "We report on the instrumentation development of a SPECT-CT system being configured at Johns Hopkins University to image the biodistribution of radiopharmaceuticals in unrestrained, unanesthetized mice. The gantry is a custom built x-ray computed tomography system based on the Siemens MicroCAT II imaging system. The x-ray system is composed of an 80 kVp (max), 4OW x-ray source and a 2048 × 3096-pixel detector (5-frames per second readout). The mouse will be anesthetized during the x-ray CT scan. SPECT imaging will be achieved using two low profile gamma cameras, 10 cm × 20 cm in size based on a 2×4 array of Hamamatsu H8500 (8×8 anode pads) flat panel position sensitive photomultiplier tubes (PSPMT). A NaI(Tl) scintillator array with 1.2 mm pitch is mounted to the PSPMT array. The front end readout electronics combine the anode outputs of the PSPMTs of the detector head. The data acquisition system is based on two CAEN 32 channel VME peak sensing analog-digital converter (ADC) modules per detector head to digitize the outputs. An infrared based animal position tracking system will be used to monitor the mouse's head position during a SPECT scan via infrared illuminated markers attached to the mouse's head. The mouse is confined in an infrared transparent burrow at the center of rotation of the gantry. The tracking system is able to track with sub-millimeter accuracy the mouse's head position at 10-15 frames per second.",

author = "Weisenberger, {A. G.} and B. Kross and S. Majewski and V. Popov and Smith, {M. F.} and Tran, {V. H.} and B. Welch and J. Baba and J. Goddard and M. Pomper and B. Tsui",

year = "2006",

doi = "10.1109/NSSMIC.2006.356506",

language = "English (US)",

isbn = "1424405610",

series = "IEEE Nuclear Science Symposium Conference Record",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "3000--3003",

booktitle = "2006 IEEE Nuclear Science Symposium - Conference Record",

note = "2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD ; Conference date: 29-10-2006 Through 04-11-2006",

}

TY - GEN

T1 - Instrumentation development of a SPECT-CT system to image awake mice

AU - Weisenberger, A. G.

AU - Kross, B.

AU - Majewski, S.

AU - Popov, V.

AU - Smith, M. F.

AU - Tran, V. H.

AU - Welch, B.

AU - Baba, J.

AU - Goddard, J.

AU - Pomper, M.

AU - Tsui, B.

PY - 2006

Y1 - 2006

N2 - We report on the instrumentation development of a SPECT-CT system being configured at Johns Hopkins University to image the biodistribution of radiopharmaceuticals in unrestrained, unanesthetized mice. The gantry is a custom built x-ray computed tomography system based on the Siemens MicroCAT II imaging system. The x-ray system is composed of an 80 kVp (max), 4OW x-ray source and a 2048 × 3096-pixel detector (5-frames per second readout). The mouse will be anesthetized during the x-ray CT scan. SPECT imaging will be achieved using two low profile gamma cameras, 10 cm × 20 cm in size based on a 2×4 array of Hamamatsu H8500 (8×8 anode pads) flat panel position sensitive photomultiplier tubes (PSPMT). A NaI(Tl) scintillator array with 1.2 mm pitch is mounted to the PSPMT array. The front end readout electronics combine the anode outputs of the PSPMTs of the detector head. The data acquisition system is based on two CAEN 32 channel VME peak sensing analog-digital converter (ADC) modules per detector head to digitize the outputs. An infrared based animal position tracking system will be used to monitor the mouse's head position during a SPECT scan via infrared illuminated markers attached to the mouse's head. The mouse is confined in an infrared transparent burrow at the center of rotation of the gantry. The tracking system is able to track with sub-millimeter accuracy the mouse's head position at 10-15 frames per second.

AB - We report on the instrumentation development of a SPECT-CT system being configured at Johns Hopkins University to image the biodistribution of radiopharmaceuticals in unrestrained, unanesthetized mice. The gantry is a custom built x-ray computed tomography system based on the Siemens MicroCAT II imaging system. The x-ray system is composed of an 80 kVp (max), 4OW x-ray source and a 2048 × 3096-pixel detector (5-frames per second readout). The mouse will be anesthetized during the x-ray CT scan. SPECT imaging will be achieved using two low profile gamma cameras, 10 cm × 20 cm in size based on a 2×4 array of Hamamatsu H8500 (8×8 anode pads) flat panel position sensitive photomultiplier tubes (PSPMT). A NaI(Tl) scintillator array with 1.2 mm pitch is mounted to the PSPMT array. The front end readout electronics combine the anode outputs of the PSPMTs of the detector head. The data acquisition system is based on two CAEN 32 channel VME peak sensing analog-digital converter (ADC) modules per detector head to digitize the outputs. An infrared based animal position tracking system will be used to monitor the mouse's head position during a SPECT scan via infrared illuminated markers attached to the mouse's head. The mouse is confined in an infrared transparent burrow at the center of rotation of the gantry. The tracking system is able to track with sub-millimeter accuracy the mouse's head position at 10-15 frames per second.

UR - http://www.scopus.com/inward/record.url?scp=38549178873&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38549178873&partnerID=8YFLogxK

U2 - 10.1109/NSSMIC.2006.356506

DO - 10.1109/NSSMIC.2006.356506

M3 - Conference contribution

AN - SCOPUS:38549178873

SN - 1424405610

SN - 9781424405619

T3 - IEEE Nuclear Science Symposium Conference Record

SP - 3000

EP - 3003

BT - 2006 IEEE Nuclear Science Symposium - Conference Record

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD

Y2 - 29 October 2006 through 4 November 2006

ER -

Instrumentation development of a SPECT-CT system to image awake mice

Abstract

Publication series

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this