Abstract
Patients with probable Alzheimer's disease (AD) were assessed neuropsychologically three times, at 6-month intervals, to identify those with patterns of performance suggesting hemispheric asymmetry in cerebral degeneration. By two different methods, over half of the patients satisfied liberal criteria for cognitive asymmetry on one or more assessments, but only 12-15% did so on all three visits. This is the proportion expected by chance. The small, stable Low Verbal and Low Spatial groups did not differ from each other, nor from the globally impaired group, on clinical or demographic variables. The Low Spatial patients identified by either method had the earliest age of onset and had shorter durations of illness. Limited autopsy data suggest that AD patients with cognitive asymmetries are more likely to have brain pathology in addition to that typical of AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 449-458 |
| Number of pages | 10 |
| Journal | Journal of Clinical and Experimental Neuropsychology |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 1 1995 |
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ASJC Scopus subject areas
- Clinical Neurology
- Clinical Psychology
- Neurology
- Psychology(all)
Cite this
Instability of Cognitive Asymmetry in Alzheimer's Disease. / Rasmusson, D. Xeno; Brandt, Jason.
In: Journal of Clinical and Experimental Neuropsychology, Vol. 17, No. 3, 01.06.1995, p. 449-458.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Instability of Cognitive Asymmetry in Alzheimer's Disease
AU - Rasmusson, D. Xeno
AU - Brandt, Jason
PY - 1995/6/1
Y1 - 1995/6/1
N2 - Patients with probable Alzheimer's disease (AD) were assessed neuropsychologically three times, at 6-month intervals, to identify those with patterns of performance suggesting hemispheric asymmetry in cerebral degeneration. By two different methods, over half of the patients satisfied liberal criteria for cognitive asymmetry on one or more assessments, but only 12-15% did so on all three visits. This is the proportion expected by chance. The small, stable Low Verbal and Low Spatial groups did not differ from each other, nor from the globally impaired group, on clinical or demographic variables. The Low Spatial patients identified by either method had the earliest age of onset and had shorter durations of illness. Limited autopsy data suggest that AD patients with cognitive asymmetries are more likely to have brain pathology in addition to that typical of AD.
AB - Patients with probable Alzheimer's disease (AD) were assessed neuropsychologically three times, at 6-month intervals, to identify those with patterns of performance suggesting hemispheric asymmetry in cerebral degeneration. By two different methods, over half of the patients satisfied liberal criteria for cognitive asymmetry on one or more assessments, but only 12-15% did so on all three visits. This is the proportion expected by chance. The small, stable Low Verbal and Low Spatial groups did not differ from each other, nor from the globally impaired group, on clinical or demographic variables. The Low Spatial patients identified by either method had the earliest age of onset and had shorter durations of illness. Limited autopsy data suggest that AD patients with cognitive asymmetries are more likely to have brain pathology in addition to that typical of AD.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029041998&partnerID=8YFLogxK
U2 - 10.1080/01688639508405136
DO - 10.1080/01688639508405136
M3 - Article
C2 - 7650106
AN - SCOPUS:0029041998
VL - 17
SP - 449
EP - 458
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
SN - 1380-3395
IS - 3
ER -